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2021-03-18Zeitschriftenartikel
Non-Toxic Glycosylated Gold Nanoparticle-Amphotericin B Conjugates Reduce Biofilms and Intracellular Burden of Fungi and Parasites
dc.contributor.authorGhosh, Chandradhish
dc.contributor.authorVarela-Aramburu, Silvia
dc.contributor.authorEldesouky, Hassan E.
dc.contributor.authorSalehi Hossainy, Sharareh
dc.contributor.authorSeleem, Mohamed N.
dc.contributor.authorAebischer, Toni
dc.contributor.authorSeeberger, Peter H.
dc.date.accessioned2024-08-13T13:54:52Z
dc.date.available2024-08-13T13:54:52Z
dc.date.issued2021-03-18none
dc.identifier.other10.1002/adtp.202000293
dc.identifier.urihttp://edoc.rki.de/176904/11904
dc.description.abstractInfections by intracellular pathogens cause significant morbidity and mortality due to lack of efficient drug delivery. Amphotericin B, currently used to treat leishmaniasis and cryptococcosis, is very toxic and cannot eradicate intracellular Cryptococcus neoformans (C. neoformans). Glycosylated gold nanoparticles are water dispersible and biocompatible with very little toxicity. While amphotericin B is insoluble in water at neutral pH, conjugates of amphotericin B and ultra-small gold nanoparticles (AuNP) are better dispersible in water. Amphotericin B conjugated glycosylated gold nanoparticles (AmpoB@AuNP) are more efficacious in treating both extracellular and intracellular forms of Leishmania mexicana (L. mexicana) than amphotericin B alone. In addition, AmpoB@AuNP are effective in reducing C. neoformans biofilms by 80% and intracellular C. neoformans burden by >90%. Furthermore, AmpoB@AuNP are not haemolytic at 50 µg mL−1 and are significantly less toxic to murine macrophages than amphotericin B. Ultra-small AuNPs are attractive delivery agents to treat intracellular infections and AmpoB@AuNP may be useful for treating C. neoformans infections in immunocompromised patients.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY-NC-ND 3.0 DE) Namensnennung - Nicht-kommerziell - Keine Bearbeitung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/de/
dc.subjectamphotericin Beng
dc.subjectcryptococcus neoformanseng
dc.subjectglycogold nanoparticleseng
dc.subjectintracellular fungieng
dc.subjectleishmania mexicanaeng
dc.subjectnanomedicineeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleNon-Toxic Glycosylated Gold Nanoparticle-Amphotericin B Conjugates Reduce Biofilms and Intracellular Burden of Fungi and Parasitesnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11904-8
dc.type.versionpublishedVersionnone
local.edoc.container-titleAdvanced Therapeuticsnone
local.edoc.container-issn2366-3987none
local.edoc.pages8none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://onlinelibrary.wiley.com/journal/23663987none
local.edoc.container-publisher-nameJohn Wiley & Sons, Incnone
local.edoc.container-reportyear2021none
dc.description.versionPeer Reviewednone

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