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2021-02-21Zeitschriftenartikel
New World camelids are sentinels for the presence of Borna disease virus
dc.contributor.authorMalbon, Alexandra J.
dc.contributor.authorDürrwald, Ralf
dc.contributor.authorKolodziejek, Jolanta
dc.contributor.authorNowotny, Norbert
dc.contributor.authorKobera, Ralph
dc.contributor.authorPöhle, Dietrich
dc.contributor.authorMuluneh, Aemero
dc.contributor.authorDervas, Eva
dc.contributor.authorCebra, Christopher
dc.contributor.authorSteffen, Frank
dc.contributor.authorPaternoster, Giulia
dc.contributor.authorGerspach, Christian
dc.contributor.authorHilbe, Monika
dc.date.accessioned2024-08-22T14:01:19Z
dc.date.available2024-08-22T14:01:19Z
dc.date.issued2021-02-21none
dc.identifier.other10.1111/tbed.14003
dc.identifier.urihttp://edoc.rki.de/176904/11940
dc.description.abstractBorna disease (BD), a frequently fatal neurologic disorder caused by Borna disease virus 1 (BoDV-1), has been observed for decades in horses, sheep, and other mammals in certain regions of Europe. The bicoloured white-toothed shrew (Crocidura leucodon) was identified as a persistently infected species involved in virus transmission. Recently, BoDV-1 attracted attention as a cause of fatal encephalitis in humans. Here, we report investigations on BoDV-1-infected llamas from a farm in a BD endemic area of Switzerland, and alpacas from holdings in a region of Germany where BD was last seen in the 1960s but not thereafter. All New World camelids showed apathy and abnormal behaviour, necessitating euthanasia. Histologically, severe non-suppurative meningoencephalitis with neuronal Joest-Degen inclusion bodies was observed. BoDV-1 was confirmed by immunohistology, RT-qPCR, and sequencing in selected animals. Analysis of the llama herd over 20 years showed that losses due to clinically suspected BD increased within the last decade. BoDV-1 whole-genome sequences from one Swiss llama and one German alpaca and—for comparison—from one Swiss horse and one German shrew were established. They represent the first published whole-genome sequences of BoDV-1 clusters 1B and 3, respectively. Our analysis suggests that New World camelids may have a role as a sentinel species for BoDV-1 infection, even when symptomatic cases are lacking in other animal species.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectalpacaeng
dc.subjectborna disease viruseng
dc.subjectbornaviruseng
dc.subjectencephalitiseng
dc.subjectllamaeng
dc.subjectnew world camelidseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleNew World camelids are sentinels for the presence of Borna disease virusnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11940-8
dc.type.versionpublishedVersionnone
local.edoc.container-titleTransboundary and Emerging Diseasesnone
local.edoc.container-issn1865-1682none
local.edoc.pages14none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://onlinelibrary.wiley.com/journal/tbednone
local.edoc.container-publisher-nameJohn Wiley & Sons, Incnone
local.edoc.container-volume69none
local.edoc.container-firstpage451none
local.edoc.container-lastpage464none
dc.description.versionPeer Reviewednone

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