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2021-05-02Zeitschriftenartikel
Prevalence and early-life risk factors of school-age allergic multimorbidity: The EuroPrevall-iFAAM birth cohort
dc.contributor.authorSigurdardottir, Sigurveig T.
dc.contributor.authorJonasson, Kristjan
dc.contributor.authorClausen, Michael
dc.contributor.authorBjornsdottir, Kristin Lilja
dc.contributor.authorSigurdardottir, Sigridur Erla
dc.contributor.authorRoberts, Graham
dc.contributor.authorGrimshaw, Kate
dc.contributor.authorPapadopoulos, Nikolaos G.
dc.contributor.authorXepapadaki, Paraskevi
dc.contributor.authorFiandor, Ana
dc.contributor.authorQuirce, Santiago
dc.contributor.authorSprikkelman, Aline B.
dc.contributor.authorHulshof, Lies
dc.contributor.authorKowalski, Marek L.
dc.contributor.authorKurowski, Marcin
dc.contributor.authorDubakiene, Ruta
dc.contributor.authorRudzeviciene, Odilija
dc.contributor.authorBellach, Johanna
dc.contributor.authorYürek, Songül
dc.contributor.authorReich, Andreas
dc.contributor.authorErhard, Sina Maria
dc.contributor.authorCouch, Philip
dc.contributor.authorRivas, Montserrat Fernandez
dc.contributor.authorvan Ree, Ronald
dc.contributor.authorMills, Clare
dc.contributor.authorGrabenhenrich, Linus
dc.contributor.authorBeyer, Kirsten
dc.contributor.authorKeil, Thomas
dc.date.accessioned2024-08-26T11:38:59Z
dc.date.available2024-08-26T11:38:59Z
dc.date.issued2021-05-02none
dc.identifier.other10.1111/all.14857
dc.identifier.urihttp://edoc.rki.de/176904/11964
dc.description.abstractBackground Coexistence of childhood asthma, eczema and allergic rhinitis is higher than can be expected by chance, suggesting a common mechanism. Data on allergic multimorbidity from a pan-European, population-based birth cohort study have been lacking. This study compares the prevalence and early-life risk factors of these diseases in European primary school children. Methods In the prospective multicentre observational EuroPrevall-iFAAM birth cohort study, we used standardized questionnaires on sociodemographics, medical history, parental allergies and lifestyle, and environmental exposures at birth, 12 and 24 months. At primary school age, parents answered ISAAC-based questions on current asthma, rhinitis and eczema. Allergic multimorbidity was defined as the coexistence of at least two of these. Results From 10,563 children recruited at birth in 8 study centres, we included data from 5,572 children (mean age 8.2 years; 51.8% boys). Prevalence estimates were as follows: asthma, 8.1%; allergic rhinitis, 13.3%; and eczema, 12.0%. Allergic multimorbidity was seen in 7.0% of the whole cohort, ranging from 1.2% (Athens, Greece) to 10.9% (Madrid, Spain). Risk factors for allergic multimorbidity, identified with AICc, included family-allergy-score, odds ratio (OR) 1.50 (95% CI 1.32–1.70) per standard deviation; early-life allergy symptoms, OR 2.72 (2.34–3.16) for each symptom; and caesarean birth, OR 1.35 (1.04–1.76). Female gender, OR 0.72 (0.58–0.90); older siblings, OR 0.79 (0.63–0.99); and day care, OR 0.81 (0.63–1.06) were protective factors. Conclusion Allergic multimorbidity should be regarded as an important chronic childhood disease in Europe. Some of the associated early-life factors are modifiable and may be considered for prevention strategies.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY-NC 3.0 DE) Namensnennung - Nicht kommerziell 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/de/
dc.subjectallergic multimorbidityeng
dc.subjectallergic rhinitiseng
dc.subjectasthmaeng
dc.subjectchildreneng
dc.subjecteczemaeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titlePrevalence and early-life risk factors of school-age allergic multimorbidity: The EuroPrevall-iFAAM birth cohortnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11964-6
dc.type.versionpublishedVersionnone
local.edoc.container-titleAllergynone
local.edoc.container-issn1398-9995none
local.edoc.pages11none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://onlinelibrary.wiley.com/journal/13989995none
local.edoc.container-publisher-nameJohn Wiley & Sons, Incnone
local.edoc.container-volume76none
local.edoc.container-issue9none
local.edoc.container-reportyear2021none
local.edoc.container-firstpage2855none
local.edoc.container-lastpage2865none
dc.description.versionPeer Reviewednone

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