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2021-08-10Zeitschriftenartikel
Investigation of fatal human Borna disease virus 1 encephalitis outside the previously known area for human cases, Brandenburg, Germany – a case report
dc.contributor.authorTappe, Dennis
dc.contributor.authorPörtner, Kirsten
dc.contributor.authorFrank, Christina
dc.contributor.authorWilking, Hendrik
dc.contributor.authorEbinger, Arnt
dc.contributor.authorHerden, Christiane
dc.contributor.authorSchulze, Christoph
dc.contributor.authorMuntau, Birgit
dc.contributor.authorEggert, Petra
dc.contributor.authorAllartz, Petra
dc.contributor.authorSchuldt, Gerlind
dc.contributor.authorSchmidt-Chanasit, Jonas
dc.contributor.authorBeer, Martin
dc.contributor.authorRubbenstroh, Dennis
dc.date.accessioned2024-08-26T13:07:28Z
dc.date.available2024-08-26T13:07:28Z
dc.date.issued2021-08-10none
dc.identifier.other10.1186/s12879-021-06439-3
dc.identifier.urihttp://edoc.rki.de/176904/11970
dc.description.abstractBackground The true burden and geographical distribution of human Borna disease virus 1 (BoDV-1) encephalitis is unknown. All detected cases so far have been recorded in Bavaria, southern Germany. Case presentation A retrospective laboratory and epidemiological investigation of a 2017 case of fatal encephalitis in a farmer in Brandenburg, northeast Germany, demonstrated BoDV-1 as causative agent by polymerase chain reaction, immunohistochemistry and in situ hybridization. Next-generation sequencing showed that the virus belonged to a cluster not known to be endemic in Brandenburg. The investigation was triggered by a recent outbreak of animal Borna disease in the region. Multiple possible exposures were identified. The next-of-kin were seronegative. Conclusions The investigation highlights clinical awareness for human BoDV-1 encephalitis which should be extended to all areas endemic for animal Borna disease. All previously diagnosed human cases had occurred > 350 km further south. Further testing of shrews and livestock with Borna disease may show whether this BoDV-1 cluster is additionally endemic in the northwest of Brandenburg.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectbornaviruseng
dc.subjectBoDV-1eng
dc.subjectclinical awarenesseng
dc.subjectphylogenyeng
dc.subjectcase reporteng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleInvestigation of fatal human Borna disease virus 1 encephalitis outside the previously known area for human cases, Brandenburg, Germany – a case reportnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11970-2
dc.type.versionpublishedVersionnone
local.edoc.container-titleBMC Infectious Diseasesnone
local.edoc.container-issn1471-2334none
local.edoc.pages5none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://bmcinfectdis.biomedcentral.com/none
local.edoc.container-publisher-nameSpringer Naturenone
local.edoc.container-volume21none
local.edoc.container-reportyear2021none
dc.description.versionPeer Reviewednone

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