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2021-03-30Zeitschriftenartikel
The global dissemination of hospital clones of Enterococcus faecium
dc.contributor.authorvan Hal, Sebastiaan J.
dc.contributor.authorWilems, Rob J.L.
dc.contributor.authorGouliouris, Theodore
dc.contributor.authorBallard, Susan A.
dc.contributor.authorCoque, Teresa M.
dc.contributor.authorHammerum, Anette M.
dc.contributor.authorHegstad, Kristin
dc.contributor.authorWesth, Hendrik T.
dc.contributor.authorHowden, Benjamin P.
dc.contributor.authorMalhotra-Kumar, Surbhi
dc.contributor.authorWerner, Guido
dc.contributor.authorYanagihara, Katsunori
dc.contributor.authorEarl, Ashlee M.
dc.contributor.authorRaven, Katherine E.
dc.contributor.authorCorander, Jukka
dc.contributor.authorBowden, Rory
dc.contributor.authorEnterococcal Group
dc.date.accessioned2024-08-26T15:49:27Z
dc.date.available2024-08-26T15:49:27Z
dc.date.issued2021-03-30none
dc.identifier.other10.1186/s13073-021-00868-0
dc.identifier.urihttp://edoc.rki.de/176904/11978
dc.description.abstractBackground The hospital-adapted A1 group of Enterococcus faecium remains an organism of significant concern in the context of drug-resistant hospital-associated infections. How this pathogen evolves and disseminates remains poorly understood. Methods A large, globally representative collection of short-read genomic data from the hospital-associated A1 group of Enterococcus faecium was assembled (n = 973). We analysed, using a novel analysis approach, global diversity in terms of both the dynamics of the accessory genome and homologous recombination among conserved genes. Results Two main modes of genomic evolution continue to shape E. faecium: the acquisition and loss of genes, including antimicrobial resistance genes, through mobile genetic elements including plasmids, and homologous recombination of the core genome. These events lead to new clones emerging at the local level, followed by the erosion of signals of clonality through recombination, and in some identifiable cases producing new clonal clusters. These patterns lead to new, emerging lineages which are able to spread globally over relatively short timeframes. Conclusions The ability of A1 E. faecium to continually present new combinations of genes for potential selection suggests that controlling this pathogen will remain challenging but establishing a framework for understanding genomic evolution is likely to aid in tracking the threats posed by newly emerging lineages.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleThe global dissemination of hospital clones of Enterococcus faeciumnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11978-0
dc.type.versionpublishedVersionnone
local.edoc.container-titleGenome Medicinenone
local.edoc.container-issn1756-994Xnone
local.edoc.pages12none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeseries
local.edoc.container-type-nameSchriftenreihe
local.edoc.container-urlhttps://genomemedicine.biomedcentral.com/none
local.edoc.container-publisher-nameSpringer Naturenone
local.edoc.container-volume13none
local.edoc.container-reportyear2021none
dc.description.versionPeer Reviewednone

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