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2021-03-15Zeitschriftenartikel
Discovery of Novel Herpes Simplexviruses in Wild Gorillas, Bonobos, and Chimpanzees Supports Zoonotic Origin of HSV-2
dc.contributor.authorWertheim, Joel O.
dc.contributor.authorHostager, Reilly
dc.contributor.authorRyu, Diane
dc.contributor.authorMerkel, Kevin
dc.contributor.authorAngedakin, Samuel
dc.contributor.authorArandjelovic, Mimi
dc.contributor.authorAyimisin, Emmanuel Ayuk
dc.contributor.authorBabweteera, Fred
dc.contributor.authorBessone, Mattia
dc.contributor.authorBrun-Jeffrey, Kathryn J.
dc.contributor.authorDieguez, Paula
dc.contributor.authorEckardt, Winnie
dc.contributor.authorFruth, Barbara
dc.contributor.authorHerbinger, Ilka
dc.contributor.authorJones, Sorrel
dc.contributor.authorKuehl, Hjalmar
dc.contributor.authorLangergraber, Kevin E.
dc.contributor.authorLee, Kevin
dc.contributor.authorMadinda, Nadege F.
dc.contributor.authorMetzger, Sonja
dc.contributor.authorOrmsby, Lucy Jayne
dc.contributor.authorRobbins, Martha M.
dc.contributor.authorSommer, Volker
dc.contributor.authorStoinski, Tara
dc.contributor.authorWessling, Erin G.
dc.contributor.authorWittig, Roman M.
dc.contributor.authorYuh, Yisa Ginath
dc.contributor.authorLeendertz, Fabian H.
dc.contributor.authorCalvignac-Spencer, Sébastien
dc.date.accessioned2024-08-26T17:06:57Z
dc.date.available2024-08-26T17:06:57Z
dc.date.issued2021-03-15none
dc.identifier.other10.1093/molbev/msab072
dc.identifier.urihttp://edoc.rki.de/176904/11981
dc.description.abstractViruses closely related to human pathogens can reveal the origins of human infectious diseases. Human herpes simplexvirus type 1 (HSV-1) and type 2 (HSV-2) are hypothesized to have arisen via host-virus codivergence and cross-species transmission. We report the discovery of novel herpes simplexviruses during a large-scale screening of fecal samples from wild gorillas, bonobos, and chimpanzees. Phylogenetic analysis indicates that, contrary to expectation, simplexviruses from these African apes are all more closely related to HSV-2 than to HSV-1. Molecular clock-based hypothesis testing suggests the divergence between HSV-1 and the African great ape simplexviruses likely represents a codivergence event between humans and gorillas. The simplexviruses infecting African great apes subsequently experienced multiple cross-species transmission events over the past 3 My, the most recent of which occurred between humans and bonobos around 1 Ma. These findings revise our understanding of the origins of human herpes simplexviruses and suggest that HSV-2 is one of the earliest zoonotic pathogens.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY-NC 3.0 DE) Namensnennung - Nicht kommerziell 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/de/
dc.subjectphylogeneticseng
dc.subjectzoonosiseng
dc.subjectherpesviruseng
dc.subjectmolecular clockeng
dc.subjectapeeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleDiscovery of Novel Herpes Simplexviruses in Wild Gorillas, Bonobos, and Chimpanzees Supports Zoonotic Origin of HSV-2none
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11981-1
dc.type.versionpublishedVersionnone
local.edoc.container-titleMolecular Biology and Evolutionnone
local.edoc.container-issn1537-1719none
local.edoc.pages13none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://academic.oup.com/mbenone
local.edoc.container-publisher-nameOxford University Pressnone
local.edoc.container-volume38none
local.edoc.container-reportyear2021none
local.edoc.container-firstpage2818none
local.edoc.container-lastpage2830none
dc.description.versionPeer Reviewednone
local.edoc.container-erstkatid7none

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