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2021-09-02Zeitschriftenartikel
Small-molecule polymerase inhibitor protects non-human primates from measles and reduces shedding
dc.contributor.authorWittwer, Kevin
dc.contributor.authorAnderson, Danielle
dc.contributor.authorPfeffermann, Kristin
dc.contributor.authorCox, Robert M.
dc.contributor.authorWolf, Josef D.
dc.contributor.authorSantibanez, Sabine
dc.contributor.authorMankertz, Annette
dc.contributor.authorPlesker, Roland
dc.contributor.authorSticher, Zachary M.
dc.contributor.authorKolkykhalov, Alexander A.
dc.contributor.authorNatchus, Michael G.
dc.contributor.authorPfaller, Christian K.
dc.contributor.authorPlemper, Richard K.
dc.contributor.authorvon Messling, Veronika
dc.date.accessioned2024-08-26T17:23:27Z
dc.date.available2024-08-26T17:23:27Z
dc.date.issued2021-09-02none
dc.identifier.other10.1038/s41467-021-25497-4
dc.identifier.urihttp://edoc.rki.de/176904/11983
dc.description.abstractMeasles virus (MeV) is a highly contagious pathogen that enters the human host via the respiratory route. Besides acute pathologies including fever, cough and the characteristic measles rash, the infection of lymphocytes leads to substantial immunosuppression that can exacerbate the outcome of infections with additional pathogens. Despite the availability of effective vaccine prophylaxis, measles outbreaks continue to occur worldwide. We demonstrate that prophylactic and post-exposure therapeutic treatment with an orally bioavailable small-molecule polymerase inhibitor, ERDRP-0519, prevents measles disease in squirrel monkeys (Saimiri sciureus). Treatment initiation at the onset of clinical signs reduced virus shedding, which may support outbreak control. Results show that this clinical candidate has the potential to alleviate clinical measles and augment measles virus eradication.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleSmall-molecule polymerase inhibitor protects non-human primates from measles and reduces sheddingnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11983-1
dc.type.versionpublishedVersionnone
local.edoc.container-titleNature Communicationsnone
local.edoc.container-issn2041-1723none
local.edoc.pages7none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.nature.com/ncomms/none
local.edoc.container-publisher-nameSpringer Naturenone
local.edoc.container-volume12none
local.edoc.container-reportyear2021none
dc.description.versionPeer Reviewednone

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