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2022-11-14Zeitschriftenartikel
Nationally representative results on SARS-CoV-2 seroprevalence and testing in Germany at the end of 2020
dc.contributor.authorNeuhauser, Hannelore
dc.contributor.authorRosario, Angelika Schaffrath
dc.contributor.authorButschalowsky, Hans
dc.contributor.authorHaller, Sebastian
dc.contributor.authorHoebel, Jens
dc.contributor.authorMichel, Janine
dc.contributor.authorNitsche, Andreas
dc.contributor.authorPhoetko-Mueller, Christina
dc.contributor.authorPrütz, Franziska
dc.contributor.authorSchlaud, Martin
dc.contributor.authorSteinhauer, Hans W.
dc.contributor.authorWilking, Hendrik
dc.contributor.authorWieler, Lothar H.
dc.contributor.authorSchaade, Lars
dc.contributor.authorLiebig, Stefan
dc.contributor.authorGößwald, Antje
dc.contributor.authorGrabka, Markus M.
dc.contributor.authorZinn, Sabine
dc.contributor.authorZiese, Thomas
dc.date.accessioned2024-08-29T07:45:32Z
dc.date.available2024-08-29T07:45:32Z
dc.date.issued2022-11-14none
dc.identifier.other10.1038/s41598-022-23821-6
dc.identifier.urihttp://edoc.rki.de/176904/12019
dc.description.abstractPre-vaccine SARS-CoV-2 seroprevalence data from Germany are scarce outside hotspots, and socioeconomic disparities remained largely unexplored. The nationwide representative RKI-SOEP study (15,122 participants, 18–99 years, 54% women) investigated seroprevalence and testing in a supplementary wave of the Socio-Economic-Panel conducted predominantly in October–November 2020. Self-collected oral-nasal swabs were PCR-positive in 0.4% and Euroimmun anti-SARS-CoV-2-S1-IgG ELISA from dry-capillary-blood antibody-positive in 1.3% (95% CI 0.9–1.7%, population-weighted, corrected for sensitivity = 0.811, specificity = 0.997). Seroprevalence was 1.7% (95% CI 1.2–2.3%) when additionally correcting for antibody decay. Overall infection prevalence including self-reports was 2.1%. We estimate 45% (95% CI 21–60%) undetected cases and lower detection in socioeconomically deprived districts. Prior SARS-CoV-2 testing was reported by 18% from the lower educational group vs. 25% and 26% from the medium and high educational group (p < 0.001, global test over three categories). Symptom-triggered test frequency was similar across educational groups. Routine testing was more common in low-educated adults, whereas travel-related testing and testing after contact with infected persons was more common in highly educated groups. This countrywide very low pre-vaccine seroprevalence in Germany at the end of 2020 can serve to evaluate the containment strategy. Our findings on social disparities indicate improvement potential in pandemic planning for people in socially disadvantaged circumstances.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleNationally representative results on SARS-CoV-2 seroprevalence and testing in Germany at the end of 2020none
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/12019-9
dc.type.versionpublishedVersionnone
local.edoc.container-titlescientific reportsnone
local.edoc.container-issn2045-2322none
local.edoc.pages13none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.nature.com/srep/none
local.edoc.container-publisher-nameSpringer Naturenone
local.edoc.container-volume12none
local.edoc.container-reportyear2022none
dc.description.versionPeer Reviewednone

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