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2022-10-27Zeitschriftenartikel
SARS-CoV-2 Omicron variant is attenuated for replication in a polarized human lung epithelial cell model
dc.contributor.authorMache, Christin
dc.contributor.authorSchulze, Jessica
dc.contributor.authorHolland, Gudrun
dc.contributor.authorBourqain, Daniel
dc.contributor.authorGensch, Jean-Marc
dc.contributor.authorOh, Djin-Ye
dc.contributor.authorNitsche, Andreas
dc.contributor.authorDürrwald, Ralf
dc.contributor.authorLaue, Michael
dc.contributor.authorWolff, Thorsten
dc.date.accessioned2024-08-29T08:11:49Z
dc.date.available2024-08-29T08:11:49Z
dc.date.issued2022-10-27none
dc.identifier.other10.1038/s42003-022-04068-3
dc.identifier.urihttp://edoc.rki.de/176904/12022
dc.description.abstractSARS-CoV-2 and its emerging variants of concern remain a major threat for global health. Here we introduce an infection model based upon polarized human Alveolar Epithelial Lentivirus immortalized (hAELVi) cells grown at the air–liquid interface to estimate replication and epidemic potential of respiratory viruses in the human lower respiratory tract. hAELVI cultures are highly permissive for different human coronaviruses and seasonal influenza A virus and upregulate various mediators following virus infection. Our analysis revealed a significantly reduced capacity of SARS-CoV-2 Omicron BA.1 and BA.2 variants to propagate in this human model compared to earlier D614G and Delta variants, which extends early risk assessments from epidemiological and animal studies suggesting a reduced pathogenicity of Omicron.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleSARS-CoV-2 Omicron variant is attenuated for replication in a polarized human lung epithelial cell modelnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/12022-3
dc.type.versionpublishedVersionnone
local.edoc.container-titlecommunications biologynone
local.edoc.container-issn2399-3642none
local.edoc.pages8none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.nature.com/commsbio/none
local.edoc.container-publisher-nameSpringer Naturenone
local.edoc.container-volume5none
local.edoc.container-reportyear2022none
dc.description.versionPeer Reviewednone

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