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2022-03-15Zeitschriftenartikel
First Report of a Methicillin-Resistant, High-Level Mupirocin-Resistant Staphylococcus argenteus
dc.contributor.authorShittu, Adebayo Osagie
dc.contributor.authorLayer-Nicolaou, Franziska
dc.contributor.authorStrommenger, Birgit
dc.contributor.authorNguyen, Minh-Thu
dc.contributor.authorBletz, Stefan
dc.contributor.authorMellmann, Alexander
dc.contributor.authorSchaumburg, Frieder
dc.date.accessioned2024-09-03T13:18:22Z
dc.date.available2024-09-03T13:18:22Z
dc.date.issued2022-03-15none
dc.identifier.other10.3389/fcimb.2022.860163
dc.identifier.urihttp://edoc.rki.de/176904/12073
dc.description.abstractWe describe the identification of a methicillin-resistant, high-level mupirocin-resistant Staphylococcus argenteus. The isolate (1801221) was characterized as t6675-ST2250-SCCmecIVc, and whole-genome sequencing revealed that the isolate possessed two plasmids. One plasmid (34,870 bp), designated p1_1801221 with rep23, harboured the mupirocin resistance (mupA) gene. The second plasmid (20,644 bp), assigned as p2_1801221 with rep5a and rep16, carried the resistance determinants for penicillin (blaZ) and cadmium (cadD). Phylogenetic analysis revealed that the isolate clustered with the European ST2250 lineage. The overall high similarity of both plasmids in S. argenteus with published DNA sequences of Staphylococcus aureus plasmids strongly suggests an interspecies transfer. The pathogenic potential, community and nosocomial spread, and acquisition of antibiotic resistance gene determinants, including the mupA gene by S. argenteus, highlight its clinical significance and the need for its correct identificationeng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectidentificationeng
dc.subjectmethicillin-resistanteng
dc.subjectstaphylococcus argenteuseng
dc.subjecthigh-level mupirocin resistanceeng
dc.subjectplasmideng
dc.subjectwhole-genome sequencing (WGS)eng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleFirst Report of a Methicillin-Resistant, High-Level Mupirocin-Resistant Staphylococcus argenteusnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/12073-0
dc.type.versionpublishedVersionnone
local.edoc.container-titleFrontiers in Cellular and Infection Microbiologynone
local.edoc.container-issn2235-2988none
local.edoc.pages7none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.frontiersin.org/journals/cellular-and-infection-microbiologynone
local.edoc.container-publisher-nameFrontiers Meadia S.A.none
local.edoc.container-volume12none
local.edoc.container-reportyear2022none
dc.description.versionPeer Reviewednone

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