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2022-03-21Zeitschriftenartikel
Cluster of human Puumala orthohantavirus infections due to indoor exposure?—An interdisciplinary outbreak investigation
dc.contributor.authorPrinck, Christina
dc.contributor.authorDrewes, Stephan
dc.contributor.authorMeyer-Schlinkmann, Kristin M.
dc.contributor.authorSaathoff, Marion
dc.contributor.authorBinder, Florian
dc.contributor.authorFreise, Jona
dc.contributor.authorTenner, Beate
dc.contributor.authorWeiss, Sabrina
dc.contributor.authorHofmann, Jörg
dc.contributor.authorEsser, Jutta
dc.contributor.authorRunge, Martin
dc.contributor.authorJacob, Jens
dc.contributor.authorUlrich, Rainer G.
dc.contributor.authorDreesman, Johannes
dc.date.accessioned2024-09-04T12:45:36Z
dc.date.available2024-09-04T12:45:36Z
dc.date.issued2022-03-21none
dc.identifier.other10.1111/zph.12940
dc.identifier.urihttp://edoc.rki.de/176904/12095
dc.description.abstractPuumala orthohantavirus (PUUV) is the most important hantavirus species in Europe, causing the majority of human hantavirus disease cases. In central and western Europe, the occurrence of human infections is mainly driven by bank vole population dynamics influenced by beech mast. In Germany, hantavirus epidemic years are observed in 2- to 5-year intervals. Many of the human infections are recorded in summer and early autumn, coinciding with peaks in bank vole populations. Here, we describe a molecular epidemiological investigation in a small company with eight employees of whom five contracted hantavirus infections in late 2017. Standardized interviews with employees were conducted to assess the circumstances under which the disease cluster occurred, how the employees were exposed and which counteractive measures were taken. Initially, two employees were admitted to hospital and serologically diagnosed with hantavirus infection. Subsequently, further investigations were conducted. By means of a self-administered questionnaire, three additional symptomatic cases could be identified. The hospital patients' sera were investigated and revealed in one patient a partial PUUV L segment sequence, which was identical to PUUV sequences from several bank voles collected in close proximity to company buildings. This investigation highlights the importance of a One Health approach that combines efforts from human and veterinary medicine, ecology and public health to reveal the origin of hantavirus disease clusters.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY-NC-ND 3.0 DE) Namensnennung - Nicht-kommerziell - Keine Bearbeitung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/de/
dc.subjectclethrionomys glareoluseng
dc.subjecthantavirus outbreakeng
dc.subjectoccupational exposureeng
dc.subjectone health initiativeeng
dc.subjectpuumala orthohantaviruseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleCluster of human Puumala orthohantavirus infections due to indoor exposure?—An interdisciplinary outbreak investigationnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/12095-8
dc.type.versionpublishedVersionnone
local.edoc.container-titleZoonoses and Public Healthnone
local.edoc.container-issn1836-2378none
local.edoc.pages8none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://onlinelibrary.wiley.com/journal/18632378none
local.edoc.container-publisher-nameJohn Wiley & Sons, Incnone
local.edoc.container-volume69none
local.edoc.container-issue5none
local.edoc.container-reportyear2022none
local.edoc.container-firstpage579none
local.edoc.container-lastpage586none
dc.description.versionPeer Reviewednone

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