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2022-12-21Zeitschriftenartikel
Diversity of human astroviruses in Germany 2018 and 2019
dc.contributor.authorNiendorf, Sandra
dc.contributor.authorMas Marques, Andreas
dc.contributor.authorBock, Claus-Thomas
dc.contributor.authorJacobsen, Sonja
dc.date.accessioned2024-09-05T14:56:58Z
dc.date.available2024-09-05T14:56:58Z
dc.date.issued2022-12-21none
dc.identifier.other10.1186/s12985-022-01955-3
dc.identifier.urihttp://edoc.rki.de/176904/12115
dc.description.abstractAim of this study was to investigate the molecular diversity of human astroviruses (HAstV) in Germany. A follow-up study was performed with human stool samples collected in 2018–2019, which were genotyped retrospectively. A total of 2645 stool samples, collected between January 2018 and December 2019 from sporadic cases and outbreaks of acute gastroenteritis were analyzed. An algorithm of PCR systems was used to characterize human astrovirus. Human astroviruses were found in 40 samples (positive rate: 1.6%). During the study period, children aged 1–2 years (48%) were most affected by HAstV. Genotyping revealed a number of nine circulating genotypes representing four human Mamastrovirus species. Strain MLB1 was predominant in the study population with a detection rate of 25% followed by HAstV1 with a positive rate of 20%. The diversity of astrovirus genotypes seems to be rather stable in Germany in the last years. A clustering of regionally and/or temporally linked human astroviruses in Germany was not detectable.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjecthuman astroviruseseng
dc.subjectviral gastroenteritiseng
dc.subjectmolecular surveillanceeng
dc.subjectgenotypingeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleDiversity of human astroviruses in Germany 2018 and 2019none
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/12115-7
dc.type.versionpublishedVersionnone
local.edoc.container-titleVirology Journalnone
local.edoc.container-issn1743-422Xnone
local.edoc.pages5none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://virologyj.biomedcentral.comnone
local.edoc.container-publisher-nameSpringer Naturenone
local.edoc.container-volume19none
local.edoc.container-reportyear2022none
dc.description.versionPeer Reviewednone

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