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2022-01-10Zeitschriftenartikel
Seroprevalence of mucosal and cutaneous human papillomavirus (HPV) types among children and adolescents in the general population in Germany
dc.contributor.authorLoenenbach, Anna
dc.contributor.authorPawlita, Michael
dc.contributor.authorWaterboer, Tim
dc.contributor.authorHarder, Thomas
dc.contributor.authorPhoetko-Mueller, Christina
dc.contributor.authorThamm, Michael
dc.contributor.authorLachmann, Raskit
dc.contributor.authorDeleré, Yvonne
dc.contributor.authorWichmann, Ole
dc.contributor.authorWiese-Posselt, Miriam
dc.date.accessioned2024-09-10T13:25:45Z
dc.date.available2024-09-10T13:25:45Z
dc.date.issued2022-01-10none
dc.identifier.other10.1186/s12879-022-07028-8
dc.identifier.urihttp://edoc.rki.de/176904/12140
dc.description.abstractBackground In Germany, HPV vaccination of adolescent girls was introduced in 2007. Nationally representative data on the distribution of vaccine-relevant HPV types in the pre-vaccination era are, however, only available for the adult population. To obtain data in children and adolescents, we assessed the prevalence and determinants of serological response to 16 different HPV types in a representative sample of 12,257 boys and girls aged 1–17 years living in Germany in 2003–2005. Methods Serum samples were tested for antibodies to nine mucosal and seven cutaneous HPV types. The samples had been collected during the nationally representative German Health Interview and Examination Survey for Children and Adolescents in 2003–2006. We calculated age- and gender-specific HPV seroprevalence. We used multivariable regression models to identify associations between demographic and behavioral characteristics and HPV seropositivity. Results We found low but non-zero seroprevalence for the majority of tested HPV types among children and adolescents in Germany. The overall seroprevalence of HPV-16 was 2.6%, with slightly higher values in adolescents. Seroprevalence of all mucosal types but HPV-6 ranged from 0.6% for HPV-33, to 6.4% for HPV-31 and did not differ by gender. We found high overall seroprevalence for HPV-6 with 24.8%. Cutaneous HPV type seroprevalence ranged from 4.0% for HPV-38 to 31.7% for HPV-1. In the majority of cutaneous types, seroprevalence did not differ between boys and girls, but increased sharply with age, (e.g., HPV-1 from 1.5% in 1–3-years-old to 45.1% in 10–11-years-old). Associations between behavioral factors and type-specific HPV prevalence were determined to be heterogeneous. Conclusions We report the first nationally representative data of naturally acquired HPV antibody reactivity in the pre-HPV-vaccination era among children and adolescents living in Germany. These data can be used as baseline estimates for evaluating the impact of the current HPV vaccination strategy targeting 9–14-years-old boys and girls.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjecthuman papillomaviruseng
dc.subjectseroprevalenceeng
dc.subjectrisk factorseng
dc.subjectchildreneng
dc.subjectadolescentseng
dc.subjectGermanyeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleSeroprevalence of mucosal and cutaneous human papillomavirus (HPV) types among children and adolescents in the general population in Germanynone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/12140-7
dc.type.versionpublishedVersionnone
local.edoc.container-titleBMC Infectious Diseasesnone
local.edoc.container-issn1471-2334none
local.edoc.pages14none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://bmcinfectdis.biomedcentral.com/none
local.edoc.container-publisher-nameSpringer Naturenone
local.edoc.container-volume22none
local.edoc.container-reportyear2022none
dc.description.versionPeer Reviewednone

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