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2022-05-31Zeitschriftenartikel
Resistance to Mecillinam and Nine Other Antibiotics for Oral Use in Escherichia coli Isolated from Urine Specimens of Primary Care Patients in Germany, 2019/20
dc.contributor.authorKresken, Michael
dc.contributor.authorPfeifer, Yvonne
dc.contributor.authorWagenlehner, Florian
dc.contributor.authorWerner, Guido
dc.contributor.authorWohlfarth, Esther
dc.date.accessioned2024-09-11T14:40:51Z
dc.date.available2024-09-11T14:40:51Z
dc.date.issued2022-05-31none
dc.identifier.other10.3390/antibiotics11060751
dc.identifier.urihttp://edoc.rki.de/176904/12153
dc.description.abstractUrinary tract infections (UTIs) are among the most common bacterial infections in humans. Escherichia coli is by far the leading cause of community-acquired UTIs. Pivmecillinam, the oral prodrug of the penicillin derivative mecillinam (amdinocillin), was re-introduced in Germany in March 2016 for first-line treatment of acute uncomplicated cystitis. This study aimed to evaluate the prevalence of resistance to mecillinam in comparison to nine other antibiotics used for oral treatment in E. coli urine isolates after the re-introduction of pivmecillinam. A total of 460 isolates were collected at 23 laboratories of clinical microbiology between October 2019 and March 2020. Forty-six isolates (10.0%) produced an extended-spectrum β-lactamase (ESBL) of the CTX-M family. Resistance to amoxicillin (43.3%) was most widespread, followed by resistance to trimethoprim-sulfamethoxazole (27.0%), amoxicillin-clavulanic acid (18.0%), cefuroxime (11.3%), and ciprofloxacin (11.1%). Twenty-four E. coli isolates (5.2%) were resistant to mecillinam. The concentrations of mecillinam needed to inhibit 50/90% of the ESBL-producing isolates and the remaining isolates were 1/4 mg/L and 0.5/4 mg/L, respectively. The findings support the recommendation to regard pivmecillinam as a first-line option for the treatment of uncomplicated lower UTIs.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectescherichia colieng
dc.subjecturopathogeneng
dc.subjectoutpatientseng
dc.subjectUTIeng
dc.subjectprimary careeng
dc.subjectESBLeng
dc.subjectmecillinameng
dc.subjectfosfomycineng
dc.subjectnitrofurantoineng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleResistance to Mecillinam and Nine Other Antibiotics for Oral Use in Escherichia coli Isolated from Urine Specimens of Primary Care Patients in Germany, 2019/20none
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/12153-5
dc.type.versionpublishedVersionnone
local.edoc.container-titleAntibioticsnone
local.edoc.container-issn2079-6382none
local.edoc.pages9none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.mdpi.com/journal/antibioticsnone
local.edoc.container-publisher-nameMDPInone
local.edoc.container-volume11none
local.edoc.container-issue6none
local.edoc.container-reportyear2022none
dc.description.versionPeer Reviewednone

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