Show simple item record

2022-08-03Zeitschriftenartikel
Perchlorate-specific proteomic stress responses of Debaryomyces hansenii could enable microbial survival in Martian brines
dc.contributor.authorHeinz, Jacob
dc.contributor.authorDoellinger, Joerg
dc.contributor.authorMaus, Deborah
dc.contributor.authorSchneider, Andy
dc.contributor.authorLasch, Peter
dc.contributor.authorGrossart, Hans-Peter
dc.contributor.authorSchulze-Makuch, Dirk
dc.date.accessioned2024-09-16T16:57:42Z
dc.date.available2024-09-16T16:57:42Z
dc.date.issued2022-08-03none
dc.identifier.other10.1111/1462-2920.16152
dc.identifier.urihttp://edoc.rki.de/176904/12182
dc.description.abstractIf life exists on Mars, it would face several challenges including the presence of perchlorates, which destabilize biomacromolecules by inducing chaotropic stress. However, little is known about perchlorate toxicity for microorganisms on the cellular level. Here, we present the first proteomic investigation on the perchlorate-specific stress responses of the halotolerant yeast Debaryomyces hansenii and compare these to generally known salt stress adaptations. We found that the responses to NaCl and NaClO4-induced stresses share many common metabolic features, for example, signalling pathways, elevated energy metabolism, or osmolyte biosynthesis. Nevertheless, several new perchlorate-specific stress responses could be identified, such as protein glycosylation and cell wall remodulations, presumably in order to stabilize protein structures and the cell envelope. These stress responses would also be relevant for putative life on Mars, which—given the environmental conditions—likely developed chaotropic defence strategies such as stabilized confirmations of biomacromolecules or the formation of cell clusters.ger
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titlePerchlorate-specific proteomic stress responses of Debaryomyces hansenii could enable microbial survival in Martian brinesnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/12182-4
dc.type.versionpublishedVersionnone
local.edoc.container-titleEnvironmental Microbiologynone
local.edoc.container-issn1462-2920none
local.edoc.pages15none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://enviromicro-journals.onlinelibrary.wiley.com/journal/14622920none
local.edoc.container-publisher-nameJohn Wiley & Sons, Incnone
local.edoc.container-volume24none
local.edoc.container-issue11none
local.edoc.container-reportyear2022none
local.edoc.container-firstpage5051none
local.edoc.container-lastpage5065none
dc.description.versionPeer Reviewednone

Show simple item record