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2022-12-08Zeitschriftenartikel
Different phenotypes of drug-induced anaphylaxis—Data from the European Anaphylaxis Registry
dc.contributor.authorHanschmann, Theresa
dc.contributor.authorFrancuzik, Wojciech
dc.contributor.authorDölle-Bierke, Sabine
dc.contributor.authorScherer Hofmeier, Kathrin
dc.contributor.authorGrabenhenrich, Linus
dc.contributor.authorRuëff, Franziska
dc.contributor.authorRenaudin, Jean-Marie
dc.contributor.authorPföhler, Claudia
dc.contributor.authorTreudler, Regina
dc.contributor.authorBilò, M. Beatrice
dc.contributor.authorLang, Roland
dc.contributor.authorEnsina, Luis Felipe
dc.contributor.authorChristoff, George
dc.contributor.authorCardona, Victoria
dc.contributor.authorWagner, Nicola
dc.contributor.authorReider, Norbert
dc.contributor.authorMüller, Sabine
dc.contributor.authorDickel, Heinrich
dc.contributor.authorWorm, Margitta
dc.date.accessioned2024-09-17T12:02:42Z
dc.date.available2024-09-17T12:02:42Z
dc.date.issued2022-12-08none
dc.identifier.other10.1111/all.15612
dc.identifier.urihttp://edoc.rki.de/176904/12186
dc.description.abstractBackground Drugs are a frequent cause of severe anaphylactic reactions. Here, we analyze a large dataset on drug induced anaphylaxis regarding elicitors, risk factors, symptoms, and treatment. Methods Data from the European Anaphylaxis Registry (2007–2019) with 1815 reported cases of drug-induced anaphylaxis were studied accordingly. Results Drugs are the third most frequent cause of anaphylaxis reported in the Anaphylaxis Registry. Among the eliciting groups of drugs analgesics and antibiotics were far most often reported. Female and senior patients were more frequently affected, while the number of children with DIA was low. DIA patients had symptoms affecting the skin and mucous membranes (n = 1525, 84.02%), the respiratory (n = 1300, 71.63%), the cardiovascular (n = 1251, 68.93%) and the gastrointestinal system (n = 549, 30.25%). Drugs caused significant more severe reactions, occurred more often in medical facilities and led to increased hospitalization rates in comparison to food and insect venom induced anaphylaxis. Adrenaline was used more often in patients with DIA than in anaphylaxis due to other causes. Patients with skin symptoms received more antihistamines and corticosteroids in the acute treatment, while gastrointestinal symptoms led to less adrenaline use. Conclusion The study contributes to a better understanding of DIA, with a large number of cases from Europe supporting previous data, e.g., analgesics and antibiotics being the most frequent culprits for DIA. Female gender and higher age are relevant risk factors and despite clear recommendations, the emergency treatment of DIA is not administered according to the guidelines.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY-NC 3.0 DE) Namensnennung - Nicht kommerziell 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/de/
dc.subjectanaphylaxiseng
dc.subjectdrug hypersensitivityeng
dc.subjectdrugeng
dc.subjectmulticenter studyeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleDifferent phenotypes of drug-induced anaphylaxis—Data from the European Anaphylaxis Registrynone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/12186-3
dc.type.versionpublishedVersionnone
local.edoc.container-titleAllergynone
local.edoc.container-issn1398-9995none
local.edoc.pages13none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://onlinelibrary.wiley.com/journal/13989995none
local.edoc.container-publisher-nameJohn Wiley & Sons, Incnone
local.edoc.container-volume78none
local.edoc.container-issue6none
local.edoc.container-reportyear2022none
local.edoc.container-firstpage1615none
local.edoc.container-lastpage1627none
dc.description.versionPeer Reviewednone

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