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2022-06-20Zeitschriftenartikel
West Nile Virus in Germany: An Emerging Infection and Its Relevance for Transfusion Safety
dc.contributor.authorFrank, Christina
dc.contributor.authorSchmidt-Chanasit, Jonas
dc.contributor.authorZiegler, Ute
dc.contributor.authorLachmann, Raskit
dc.contributor.authorPreußel, Karina
dc.contributor.authorOffergeld, Ruth
dc.date.accessioned2024-09-18T13:36:22Z
dc.date.available2024-09-18T13:36:22Z
dc.date.issued2022-06-20none
dc.identifier.other10.1159/000525167
dc.identifier.urihttp://edoc.rki.de/176904/12201
dc.description.abstractWest Nile virus (WNV) is an arthropod-borne virus (arbovirus). It circulates in an enzootic cycle between ornithophilic mosquitoes as vectors and reservoirs and avian host species for amplification, but humans can be infected as accidental hosts. In most individuals, WNV infection remains silent, while 20% develop mild symptoms of West Nile fever, and only 1% develop neuroinvasive disease (WNND). Human WNV cases have been identified in Southern and Eastern Europe for more than 20 years, but until 2018, Germany was considered to be a non-endemic country. This changed when in the exceptionally warm summer of 2018, conditions for viral replication in mosquitoes were ideal, and the first WNV cases among birds and horses were identified. The widespread domestic Culex mosquitoes are efficient vectors for WNV. Autochthonous mosquito-borne WNV infections in humans were reported in all following years, indicating a continuous circulation in the affected areas of Central-East Germany. So far, no clear expansion of the affected areas is discernible but may develop. WNV is a transfusion-transmissible-infection, and donor deferral or testing of donations after a stay in an affected area are effective means to ensure transfusion safety. WNV transmissions via blood products often result in WNND due to the predisposing underlying medical conditions of transfusion recipients. From 2020 onwards, roughly 80% of all blood establishments in Germany tested their donations for WNV using nucleic acid amplification techniques in the transmission season. Altogether, 19 confirmed WNV infections were identified from 2020–2021. As long as effective and affordable pathogen reduction is not available for all blood components, WNV testing or donor deferral will be essential. In order to timely identify affected areas, combined results of human and veterinary surveillance are needed. Partnerships between public health experts, transfusion medicine specialists, veterinarians, and entomologists should be strengthened to ensure a One Health approacheng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY-NC 3.0 DE) Namensnennung - Nicht kommerziell 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/de/
dc.subjectwest nile viruseng
dc.subjectvirus safetyeng
dc.subjecttransfussion-associated infectionseng
dc.subjecttransfusion riskseng
dc.subjectepidemiologyeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleWest Nile Virus in Germany: An Emerging Infection and Its Relevance for Transfusion Safetynone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/12201-8
dc.type.versionpublishedVersionnone
local.edoc.container-titleTransfusion Medicine and Hemotherapynone
local.edoc.container-issn1660-3796none
local.edoc.pages12none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://karger.com/tmhnone
local.edoc.container-publisher-nameS. Karger AGnone
local.edoc.container-volume49none
local.edoc.container-issue4none
local.edoc.container-reportyear2022none
local.edoc.container-firstpage192none
local.edoc.container-lastpage204none
dc.description.versionPeer Reviewednone

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