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2022-06-30Zeitschriftenartikel
Pilot study to identify missed opportunities for prevention of childhood tuberculosis
dc.contributor.authorFeiterna-Sperling, Cornelia
dc.contributor.authorThoulass, Janine
dc.contributor.authorKrüger, Renate
dc.contributor.authorHaas, Walter
dc.contributor.authorHauer, Barbara
dc.date.accessioned2024-09-18T14:55:28Z
dc.date.available2024-09-18T14:55:28Z
dc.date.issued2022-06-30none
dc.identifier.other10.1007/s00431-022-04537-1
dc.identifier.urihttp://edoc.rki.de/176904/12207
dc.description.abstractTuberculosis (TB) in exposed children can be prevented with timely contact tracing and preventive treatment. This study aimed to identify potential barriers and delays in the prevention of childhood TB in a low-incidence country by assessing the management of children subsequently diagnosed with TB. A pilot retrospective cohort study included children (< 15 years) treated for TB between 2009 and 2016 at a tertiary care hospital in Berlin, Germany. Clinical data on cases and source cases, information on time points of the diagnostic work up, and preventive measures were collected and analyzed. Forty-eight children (median age 3 years [range 0.25–14]) were included; 36 had been identified through contact tracing, the majority (26; 72.2%) being < 5 years. TB source cases were mostly family members, often with advanced disease. Thirty children (83.3%) did not receive prophylactic or preventive treatment, as TB was already prevalent when first presented. Three cases developed TB despite preventive or prophylactic treatment; in three cases (all < 5 years), recommendations had not been followed. Once TB was diagnosed in source cases, referral, assessment, TB diagnosis, and treatment were initiated in most children in a timely manner with a median duration of 18 days (interquartile range 6–60, range 0–252) between diagnosis of source case and child contact (information available for 35/36; 97.2%). In some cases, notable delays in follow-up occurred. Conclusion: Prompt diagnosis of adult source cases appears to be the most important challenge for childhood TB prevention. However, improvement is also needed in the management of exposed children.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectchildhood tuberculosiseng
dc.subjectscource caseeng
dc.subjectpreventive treatmenteng
dc.subjectcontact tracingeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titlePilot study to identify missed opportunities for prevention of childhood tuberculosisnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/12207-6
dc.type.versionupdatedVersionnone
local.edoc.container-titleEuropean Journal of Pediatricsnone
local.edoc.container-issn1432-1076none
local.edoc.pages9none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://link.springer.com/journal/431none
local.edoc.container-publisher-nameSpringer Naturenone
local.edoc.container-volume181none
local.edoc.container-reportyear2022none
local.edoc.container-firstpage3299none
local.edoc.container-lastpage3307none
dc.description.versionPeer Reviewednone

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