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2022-02-22Zeitschriftenartikel
Incidence of Smoking-Related Second Primary Cancers After Lung Cancer in Germany: An Analysis of Nationwide Cancer Registry Data
dc.contributor.authorEberl, Marian
dc.contributor.authorTanaka, Luana F.
dc.contributor.authorKraywinkel, Klaus
dc.contributor.authorKlug, Stefanie J.
dc.date.accessioned2024-09-18T15:23:32Z
dc.date.available2024-09-18T15:23:32Z
dc.date.issued2022-02-22none
dc.identifier.other10.1016/j.jtho.2021.11.016
dc.identifier.urihttp://edoc.rki.de/176904/12210
dc.description.abstractIntroduction Approximately 80% of lung cancer cases in Germany are attributable to smoking. Patients with a lung cancer diagnosis may remain at increased risk of developing smoking-related second primary cancers (SPCs). Methods Anonymous data from 11 population-based cancer registries covering approximately 50% of the German population were pooled for the analysis. Included patients were diagnosed with having an index lung cancer between 2002 and 2013, aged 30 to 99 years old at diagnosis, and survived for at least 6 months. We calculated standardized incidence ratios (SIRs)—stratified by age, sex, region, and period—comparing the incidence of smoking-related and other SPCs to the general population. Results Of the 135,589 lung cancer survivors (68.2% male; mean follow-up 30.8 mo) analyzed, 5298 developed an SPC. In males, the risk was particularly high for SPCs of the larynx (SIR = 3.70, 95% confidence interval [CI]: 3.14–4.34), pharynx (3.17, 2.61–3.81), and oral cavity (2.86, 2.38–3.41). For females, SIRs were notably elevated for the esophagus (4.66, 3.15–6.66), oral cavity (3.14, 2.03–4.63), and urinary tract (2.68, 2.04–3.45). When combining all smoking-related cancer sites, SIR was 1.41 in males (95% CI: 1.36–1.47) and 1.81 in females (95% CI: 1.68–1.94). We observed that males had a 1.46-fold (95% CI: 1.37–1.56) and females a 1.33-fold (95% CI: 1.20–1.47) increased risk for smoking-related compared with other cancers. Conclusions Patients with primary lung cancer were at increased risk for developing a smoking-related SPC. Therefore, the advantages of increased patient surveillance and the benefits of smoking cessation strategies should be considered.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.subjectsecond primary cancereng
dc.subjectlung cancereng
dc.subjectcancer epidemiologyeng
dc.subjectcancer registry dataeng
dc.subjectsmoking-related cancereng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleIncidence of Smoking-Related Second Primary Cancers After Lung Cancer in Germany: An Analysis of Nationwide Cancer Registry Datanone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/12210-8
dc.type.versionpublishedVersionnone
local.edoc.container-titleJournal of Thoracic Oncologynone
local.edoc.container-issn1556-1380none
local.edoc.pages11none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.sciencedirect.com/journal/journal-of-thoracic-oncologynone
local.edoc.container-publisher-nameEsnone
local.edoc.container-volume17none
local.edoc.container-issue3none
local.edoc.container-reportyear2022none
local.edoc.container-firstpage388none
local.edoc.container-lastpage398none
dc.description.versionPeer Reviewednone

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