Clinical Outcome of HIV-Infected Patients with Discordant Virological and Immunological Response to Antiretroviral Therapy
Zoufaly, Alexander
Heiden, Matthias an der
Kollan, Christian
Bogner, Johannes
Fätkenheuer, G.
Wasmuth, J. C.
Stoll, Matthias
Hamouda, Osamah
Lunzen, Jan van
Background: A subgroup of human immunodeficiency virus type 1 (HIV-1)–infected patients with severe immunodeficiency show persistently low CD4+ cell counts despite sustained viral suppression. It is unclear whether this immuno-virological discordance translates into an increased risk for clinical events. Methods: Data analysis from a large multicenter cohort incorporating 14,433 HIV-1–infected patients in Germany. Treatment-naive patients beginning antiretroviral therapy (ART) with CD4+ cell counts
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