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2022-06-09Zeitschriftenartikel
Specifically Increased Rate of Infections in Children Post Measles in a High Resource Setting
dc.contributor.authorBühl, Daniel
dc.contributor.authorStaudacher, Olga
dc.contributor.authorSantibanez, Sabine
dc.contributor.authorRossi, Rainer
dc.contributor.authorGirschick, Hermann
dc.contributor.authorStephan, Volker
dc.contributor.authorSchmidt, Beatrix
dc.contributor.authorHundsdoerfer, Patrick
dc.contributor.authorvon Moers, Arpad
dc.contributor.authorLange, Michael
dc.contributor.authorBarker, Michael
dc.contributor.authorMall, Marcus A.
dc.contributor.authorHeininger, Ulrich
dc.contributor.authorMatysiak-Klose, Dorothea
dc.contributor.authorMankertz, Annette
dc.contributor.authorvon Bernuth, Horst
dc.date.accessioned2024-09-19T15:00:16Z
dc.date.available2024-09-19T15:00:16Z
dc.date.issued2022-06-09none
dc.identifier.other10.3389/fped.2022.896086
dc.identifier.urihttp://edoc.rki.de/176904/12242
dc.description.abstractObjectives: Post-measles increased susceptibility to subsequent infections seems particularly relevant in low-resource settings. We tested the hypothesis that measles causes a specifically increased rate of infections in children, also in a high-resource setting. Methods: We conducted a retrospective cohort study on a large measles outbreak in Berlin, Germany. All children with measles who presented to hospitals in Berlin were included as cases, children with non-infectious and children with non-measles infectious diseases as controls. Repeat visits within 3 years after the outbreak were recorded. Results: We included 250 cases, 502 non-infectious, and 498 infectious disease controls. The relative risk for cases for the diagnosis of an infectious disease upon a repeat visit was 1.6 (95% CI 1.4–2.0, p < 0.001) vs. non-infectious and 1.3 (95% CI 1.1–1.6, p = 0.002) vs. infectious disease controls. 33 cases (27%), 35 non-infectious (12%) and 57 (18%) infectious disease controls presented more than three times due to an infectious disease (p = 0.01, and p = 0.02, respectively). This results in a relative risk of more than three repeat visits due to an infection for measles cases of 1.8 (95% CI 1.3–2.4, p = 0.01), and 1.4 (95% CI 1.0–1.9, p = 0.04), respectively. Conclusion: Our study demonstrates for the first time in a high-resource setting, that increased post-measles susceptibility to subsequent infections in children is measles-specific—even compared to controls with previous non-measles infections.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectmeasleseng
dc.subjectoutbreakeng
dc.subjectimmune amnesiaeng
dc.subjectEuropeeng
dc.subjecthigh resource settingeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleSpecifically Increased Rate of Infections in Children Post Measles in a High Resource Settingnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/12242-1
dc.type.versionupdatedVersionnone
local.edoc.container-titleFrontiers in Pediatricsnone
local.edoc.container-issn2296-2360none
local.edoc.pages7none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.frontiersin.org/journals/pediatricsnone
local.edoc.container-publisher-nameFrontiers Meadia S.A.none
local.edoc.container-volume10none
local.edoc.container-reportyear2022none
dc.description.versionPeer Reviewednone

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