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2022-11-16Zeitschriftenartikel
Germany’s Burden of Disease of Bloodstream Infections Due to Vancomycin-Resistant Enterococcus faecium between 2015–2020
dc.contributor.authorBrinkwirth, Simon
dc.contributor.authorMartins, Sofie
dc.contributor.authorAyobami, Olaniyi
dc.contributor.authorFeig, Marcel
dc.contributor.authorNoll, Ines
dc.contributor.authorZacher, Benedikt
dc.contributor.authorEckmanns, Tim
dc.contributor.authorWerner, Guido
dc.contributor.authorWillrich, Niklas
dc.contributor.authorHaller, Sebastian
dc.date.accessioned2024-09-19T15:46:47Z
dc.date.available2024-09-19T15:46:47Z
dc.date.issued2022-11-16none
dc.identifier.other10.3390/microorganisms10112273
dc.identifier.urihttp://edoc.rki.de/176904/12246
dc.description.abstractIn Germany, there is an increasing amount of vancomycin-resistant Enterococcus faecium (VREfm) isolates in bloodstream infections (BSIs); however, estimates on recent incidences and disease burden are missing. We aim to estimate the incidence and calculate the annual disease burden in disease-adjusted life years (DALYs) for BSIs due to VREfm in Germany between 2015 and 2020 to support informed decision-making in the field of antimicrobial resistance (AMR). We used the Antibiotic Resistance Surveillance (ARS) system data to obtain incidence estimates. The estimated incidences were used in the Burden of Communicable Disease in Europe (BCoDE) toolkit to calculate the attributable DALYs. A total of 3417 VREfm blood culture-positive isolates were observed within ARS. The estimated incidence of VREfm-BSIs per 100,000 inhabitants increased from 1.4 (95% Uncertainty Interval [UI]: 0.8–1.9) in 2015 to 2.9 (95% UI: 2.4–3.3) in 2020. The estimated burden, expressed in DALYs per 100,000 inhabitants, increased from 8.5 (95% UI: 7.3–9.7; YLD = 0.9, YLL = 7.6) in 2015 to 15.6 (95% UI: 14.6–16.6; YLD = 1.6, YLL = 14) in 2020. The most affected groups within the observed period are the 65–69-year-old males with 262.9 DALYs per 100,000 inhabitants, and in the younger age groups (<30 years), the under-one-year-old with 43.1 DALYs per 100,000 inhabitants and 34.5 DALYs for male and female, respectively. The increasing DALYs of BSIs due to VREfm require targeted prevention and control measures to address their unequal distribution across gender and age, especially for older hospitalized patients, neonates, and infants in Germany.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectburden of diseaseeng
dc.subjectbloodstream infectioneng
dc.subjectantimicrobial resistanceeng
dc.subjectvancomycin-resistanceeng
dc.subjectenterococcus faeciumeng
dc.subjectVREeng
dc.subjectVREfmeng
dc.subjectDALYseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleGermany’s Burden of Disease of Bloodstream Infections Due to Vancomycin-Resistant Enterococcus faecium between 2015–2020none
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/12246-9
dc.type.versionpublishedVersionnone
local.edoc.container-titleMicroorganismsnone
local.edoc.container-issn2076-2607none
local.edoc.pages10none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.mdpi.com/journal/microorganismsnone
local.edoc.container-publisher-nameMDPInone
local.edoc.container-volume10none
local.edoc.container-issue11none
local.edoc.container-reportyear2022none
dc.description.versionPeer Reviewednone

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