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2022-08-09Zeitschriftenartikel
Controlling an Unprecedented Outbreak with Vancomycin-Resistant Enterococcus faecium in Germany, October 2015 to November 2019
dc.contributor.authorBender, Jennifer K.
dc.contributor.authorHermes, Julia
dc.contributor.authorZabel, Lutz T.
dc.contributor.authorHaller, Sebastian
dc.contributor.authorMürter, Nadja
dc.contributor.authorBlank, Hans-Peter
dc.contributor.authorWerner, Guido
dc.contributor.authorHüttner, Ingo
dc.contributor.authorEckmanns, Tim
dc.date.accessioned2024-09-20T15:41:47Z
dc.date.available2024-09-20T15:41:47Z
dc.date.issued2022-08-09none
dc.identifier.other10.3390/microorganisms10081603
dc.identifier.urihttp://edoc.rki.de/176904/12257
dc.description.abstractHospital outbreaks with vancomycin-resistant enterococci (VRE) pose a serious health threat and a challenge to infection prevention and control (IPC). We herein report on a VRE outbreak of unprecedented extent in Southern Germany (October 2015–November 2019). We used descriptive epidemiology and whole-genome sequencing (WGS) for a detailed outbreak investigation. Of the 2905 cases, 2776 (95.3%) were colonized, whereas from 127 (3.7%), VRE could be isolated from otherwise sterile body fluids or sites unlikely for enterococci colonization. Cases had a median age of 78 years (IQR 68–84) and 1339/2905 (46%) were female. The majority of isolates sequenced belonged to the clonal lineage ST80/CT1013 (212/397, 53%). Nosocomial transmission was observed as well as the constant import of VRE into the hospital. Extensive IPC measures were implemented and terminated the outbreak in late 2019, eventually. Our study shows that the combination of epidemiological and genomic analyses is indispensable for comprehensive outbreak investigations. The adaptation of IPC measures to these findings, their timely implementation, and strict execution also allow containment of large VRE outbreaks in hospital settings.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectvancomycin-resistant enterococcieng
dc.subjecthospital outbreakeng
dc.subjecttransmissioneng
dc.subjectwhole-genome analysiseng
dc.subjectinfection prevention and control measureseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleControlling an Unprecedented Outbreak with Vancomycin-Resistant Enterococcus faecium in Germany, October 2015 to November 2019none
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/12257-9
dc.type.versionpublishedVersionnone
local.edoc.container-titleMicroorganismsnone
local.edoc.container-issn2076-2607none
local.edoc.pages13none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.mdpi.com/journal/microorganismsnone
local.edoc.container-publisher-nameMDPInone
local.edoc.container-volume10none
local.edoc.container-issue8none
local.edoc.container-reportyear2022none
dc.description.versionPeer Reviewednone

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