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2022-02-22Zeitschriftenartikel
Genomic analysis of the zoonotic ST73 lineage containing avian and human extraintestinal pathogenic Escherichia coli (ExPEC)
dc.contributor.authorSaidenberg, Andre Becker S.
dc.contributor.authorvan Vliet, Arnoud H.M.
dc.contributor.authorStegger, Marc
dc.contributor.authorJohannesen, Thor Bech
dc.contributor.authorSemmler, Torsten
dc.contributor.authorCunha, Marcos
dc.contributor.authorC. de O. Silveira, Alessandro
dc.contributor.authorKuroki Anzai, Eleine
dc.contributor.authorC.A. Scaletsky, Isabel
dc.contributor.authorDalsgaard, Anders
dc.contributor.authorLa Ragione, Roberto M.
dc.contributor.authorKnöbl, Terezinha
dc.date.accessioned2024-09-20T15:56:12Z
dc.date.available2024-09-20T15:56:12Z
dc.date.issued2022-02-22none
dc.identifier.other10.1016/j.vetmic.2022.109372
dc.identifier.urihttp://edoc.rki.de/176904/12258
dc.description.abstractExtraintestinal pathogenic Escherichia coli (ExPEC) is a globally distributed pathogen, with uropathogenic E. coli (UPEC) and sepsis-associated E. coli (SEPEC) pathotypes particularly involved in human and companion animal disease, while avian pathogenic pathotype (APEC) severely impact poultry health and production. Similarities between APEC from poultry/meat and human ExPEC suggest that some APEC lineages may have zoonotic potential. ExPEC sequence type 73 (ST73) and its clonal complex (CC) are increasing causes of urinary tract infections and sepsis, but its role in zoonotic disease is less well understood. Here, we analyzed the genome sequences of 25 E. coli isolates from Brazil (11 APEC and 14 UPEC) from two time periods, from poultry producing areas and hospitals in the same geographical regions. Isolates were compared to 558 publicly available ST73/CC73 global sequences. Brazilian APEC harbored virulence factors associated with UPEC/SEPEC such as sfa, cnf1, vat, usp, hlyA, iron acquisition and protectins/serum resistance systems, while lacking some common APEC markers and widespread multidrug resistance. Analysis of core genome MLST and SNP phylogenetic trees indicated evolutionary relationships between subgroups of the Brazilian APEC to two contemporary Brazilian UPEC isolates from the same region, and one Brazilian UPEC available from another study. Phylogenies showed a non-host, geographical, or pathotype specificity, with APEC isolates clustering closely with international human UPEC, SEPEC. The remaining Brazilian UPEC grouped within human clusters. Collectively, this suggests a zoonotic potential for subgroups of Brazilian APEC from the ST73 lineage that could contaminate poultry products and subsequently cause human infection.ger
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectAPECeng
dc.subjectescherichia colieng
dc.subjectExPECeng
dc.subjectST73eng
dc.subjectzoonosiseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleGenomic analysis of the zoonotic ST73 lineage containing avian and human extraintestinal pathogenic Escherichia coli (ExPEC)none
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/12258-3
dc.type.versionpublishedVersionnone
local.edoc.container-titleVeterinary Microbiologynone
local.edoc.container-issn1873-2542none
local.edoc.pages8none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.sciencedirect.com/journal/veterinary-microbiologynone
local.edoc.container-publisher-nameElseviernone
local.edoc.container-volume267none
local.edoc.container-reportyear2022none
dc.description.versionPeer Reviewednone

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