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2012-06-21Zeitschriftenartikel DOI: 10.1371/journal.pone.0038688
Novel paramyxoviruses in free-ranging European bats.
dc.contributor.authorKurth, Andreas
dc.contributor.authorKohl, Claudia
dc.contributor.authorBrinkmann, Annika
dc.contributor.authorEbinger, Arnt
dc.contributor.authorHarper, Jennifer A.
dc.contributor.authorWang, Lin-Fa
dc.contributor.authorMühldorfer, Kristin
dc.contributor.authorWibbelt, Gudrun
dc.date.accessioned2018-05-07T15:45:05Z
dc.date.available2018-05-07T15:45:05Z
dc.date.created2012-06-28
dc.date.issued2012-06-21none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reW2mMqWDTpw/PDF/24YIdkL2rdP0Q.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1250
dc.description.abstractThe zoonotic potential of paramyxoviruses is particularly demonstrated by their broad host range like the highly pathogenic Hendra and Nipah viruses originating from bats. But while so far all bat-borne paramyxoviruses have been identified in fruit bats across Africa, Australia, South America, and Asia, we describe the detection and characterization of the first paramyxoviruses in free-ranging European bats. Moreover, we examined the possible impact of paramyxovirus infection on individual animals by comparing histo-pathological findings and virological results. Organs from deceased insectivorous bats of various species were sampled in Germany and tested for paramyxovirus RNA in parallel to a histo-pathological examination. Nucleic acids of three novel paramyxoviruses were detected, two viruses in phylogenetic relationship to the recently proposed genus Jeilongvirus and one closely related to the genus Rubulavirus. Two infected animals revealed subclinical pathological changes within their kidneys, suggestive of a similar pathogenesis as the one described in fruit bats experimentally infected with Hendra virus.Our findings indicate the presence of bat-born paramyxoviruses in geographic areas free of fruit bat species and therefore emphasize a possible virus-host co-evolution in European bats. Since these novel viruses are related to the very distinct genera Rubulavirus and Jeilongvirus, a similarly broad genetic diversity among paramyxoviruses in other Microchiroptera compared to Megachiroptera can be assumed. Given that the infected bats were either found in close proximity to heavily populated human habitation or areas of intensive agricultural use, a potential risk of the emergence of zoonotic paramyxoviruses in Europe needs to be considered.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectAnimalseng
dc.subjectHumanseng
dc.subjectPhylogenyeng
dc.subjectGermanyeng
dc.subjectGenetic Variationeng
dc.subjectPolymerase Chain Reaction/methodseng
dc.subjectEuropeeng
dc.subjectDNA Primers/geneticseng
dc.subjectSpecies Specificityeng
dc.subjectModels Geneticeng
dc.subjectDisease Reservoirs/veterinaryeng
dc.subjectChiropteraeng
dc.subjectDisease Reservoirs/virologyeng
dc.subjectHendra Virus/geneticseng
dc.subjectKidney/metabolismeng
dc.subjectParamyxovirinae/classificationeng
dc.subjectParamyxovirinae/geneticseng
dc.subjectRNA Viral/analysiseng
dc.subject.ddc610 Medizin
dc.titleNovel paramyxoviruses in free-ranging European bats.
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10025818
dc.identifier.doi10.1371/journal.pone.0038688
dc.identifier.doihttp://dx.doi.org/10.25646/1175
local.edoc.container-titlePLoS ONE
local.edoc.container-textKurth A, Kohl C, Brinkmann A, Ebinger A, Harper JA, et al. (2012) Novel Paramyxoviruses in Free-Ranging European Bats. PLoS ONE 7(6): e38688.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0038688
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume7
local.edoc.container-issue6
local.edoc.container-year2012

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