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2012-08-14Zeitschriftenartikel DOI: 10.1371/journal.pone.0043106
Isolation and characterization of three Mammalian orthoreoviruses from European bats.
dc.contributor.authorKohl, Claudia
dc.contributor.authorLesnik, René
dc.contributor.authorBrinkmann, Annika
dc.contributor.authorEbinger, Arnt
dc.contributor.authorRadonić, Aleksandar
dc.contributor.authorNitsche, Andreas
dc.contributor.authorMühldorfer, Kristin
dc.contributor.authorWibbelt, Gudrun
dc.contributor.authorKurth, Andreas
dc.date.accessioned2018-05-07T15:48:35Z
dc.date.available2018-05-07T15:48:35Z
dc.date.created2012-09-03
dc.date.issued2012-08-14none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/re4YGdxLc45Q/PDF/27r6I8V4Dp1WM.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1269
dc.description.abstractIn recent years novel human respiratory disease agents have been described in South East Asia and Australia. The causative pathogens were classified as pteropine orthoreoviruses with strong phylogenetic relationship to orthoreoviruses of flying foxes inhabiting these regions. Subsequently, a zoonotic bat-to-human transmission has been assumed. We report the isolation of three novel mammalian orthoreoviruses (MRVs) from European bats, comprising bat-borne orthoreovirus outside of South East Asia and Australia and moreover detected in insectivorous bats (Microchiroptera). MRVs are well known to infect a broad range of mammals including man. Although they are associated with rather mild and clinically unapparent infections in their hosts, there is growing evidence of their ability to also induce more severe illness in dogs and man. In this study, eight out of 120 vespertilionid bats proved to be infected with one out of three novel MRV isolates, with a distinct organ tropism for the intestine. One isolate was analyzed by 454 genome sequencing. The obtained strain T3/Bat/Germany/342/08 had closest phylogenetic relationship to MRV strain T3D/04, isolated from a dog. These novel reoviruses provide a rare chance of gaining insight into possible transmission events and of tracing the evolution of bat viruses.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut
dc.subjectAmino Acid Sequenceeng
dc.subjectHumanseng
dc.subjectMolecular Sequence Dataeng
dc.subjectPhylogenyeng
dc.subjectAnimalseng
dc.subjectCercopithecus aethiopseng
dc.subjectRespiratory Tract Infections/virologyeng
dc.subjectPolymerase Chain Reaction/methodseng
dc.subjectDogseng
dc.subjectSequence Analysis DNAeng
dc.subjectSequence Homology Amino Acideng
dc.subjectChiropteraeng
dc.subjectVero Cellseng
dc.subjectGenome Viraleng
dc.subjectDNA Viral/metabolismeng
dc.subjectOrthoreovirus Mammalian/classificationeng
dc.subjectOrthoreovirus Mammalian/geneticseng
dc.subjectOrthoreovirus Mammalian/isolation & purificationeng
dc.subject.ddc610 Medizin
dc.titleIsolation and characterization of three Mammalian orthoreoviruses from European bats.
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10026759
dc.identifier.doi10.1371/journal.pone.0043106
dc.identifier.doihttp://dx.doi.org/10.25646/1194
local.edoc.container-titlePLoS ONE
local.edoc.container-textKohl C, Lesnik R, Brinkmann A, Ebinger A, Radonić A, et al. (2012) Isolation and Characterization of Three Mammalian Orthoreoviruses from European Bats. PLoS ONE 7(8): e43106.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0043106
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume7
local.edoc.container-issue8
local.edoc.container-year2012

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