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2023-05-04Zeitschriftenartikel
Direct and indirect vaccination effects on SARS-CoV-2 infection in day-care centres: Evaluating the policy for early vaccination of day-care staff in Germany, 2021
dc.contributor.authorSchoeps, Anja
dc.contributor.authorWalter, Jan
dc.contributor.authorVogt, Manfred
dc.contributor.authorBent, Stefan
dc.contributor.authorPhilipp, Zanger
dc.contributor.authorthe Palatina Public Health Study Group
dc.date.accessioned2025-08-01T08:32:23Z
dc.date.available2025-08-01T08:32:23Z
dc.date.issued2023-05-04none
dc.identifier.other10.1017/S0950268823000638
dc.identifier.urihttp://edoc.rki.de/176904/12872
dc.description.abstractTo mitigate the known high transmission risk in day-care facilities for children aged 0–6 years, day-care staff were given priority for SARS-CoV-2 vaccination in Rhineland-Palatinate, Germany, in March 2021. This study assessed direct and indirect effects of early vaccination of day-care staff on SARS-CoV-2 transmission in daycares with the aim to provide a basis for the prioritisation of scarce vaccines in the future. Data came from statutory infectious disease notifications in educational institutions and from in-depth investigations by the district public health authorities. Using interrupted time series analyses, we measured the effect of mRNA-based vaccination of day-care staff on SARS-CoV-2 infections and transmission. Among 566 index cases from day-care centres, the mean number of secondary SARS-CoV-2 infections per index case dropped by −0.60 case per month after March 2021. The proportion of staff among all cases reported from daycares was around 60% in the pre-interruption phase and significantly decreased by 27 percentage points immediately in March 2021 and by further 6 percentage points each month in the post-interruption phase. Early vaccination of day-care staff reduced SARS-CoV-2 cases in the overall day-care setting and thus also protected unvaccinated children. This should inform future decisions on vaccination prioritisation.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectSARS-CoV-2eng
dc.subjectVaccinationeng
dc.subjectChild Daycare Centerseng
dc.subjectStaffeng
dc.subjectInterrupted Time Series Analysiseng
dc.subjectTransmissioneng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleDirect and indirect vaccination effects on SARS-CoV-2 infection in day-care centres: Evaluating the policy for early vaccination of day-care staff in Germany, 2021none
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/12872-1
dc.type.versionpublishedVersionnone
local.edoc.container-titleEpidemiology & Infectionnone
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-publisher-nameCambridge University Pressnone
local.edoc.container-reportyear2023none
local.edoc.container-firstpage1none
local.edoc.container-lastpage4none
dc.description.versionPeer Reviewednone

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