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2012-01-30Zeitschriftenartikel DOI: 10.1128/AAC.05315-11
Emergence of OXA-48-type carbapenemase-producing Enterobacteriaceae in German hospitals
dc.contributor.authorPfeifer, Yvonne
dc.contributor.authorSchlatterer, Kathrin
dc.contributor.authorEngelmann, Elisabeth
dc.contributor.authorSchiller, Reinhold A.
dc.contributor.authorFrangenberg, Hans Reiner
dc.contributor.authorStiewe, Doris
dc.contributor.authorHolfelder, Martin
dc.contributor.authorWitte, Wolfgang
dc.contributor.authorNordmann, Patrice
dc.contributor.authorPoirel, Laurent
dc.date.accessioned2018-05-07T15:54:28Z
dc.date.available2018-05-07T15:54:28Z
dc.date.created2012-09-14
dc.date.issued2012-01-30none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reJYU7KETGFdY/PDF/27pM8OzzmjPQ.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1301
dc.description.abstractNine carbapenem-resistant Enterobacteriaceae isolates collected from eight patients in five German hospitals were investigated. Six isolates produced the OXA-48 carbapenemase, and three isolates produced OXA-162, which is a point mutant form of OXA-48. Both carbapenemase genes were located on IncL/M-type conjugative plasmids. Insertion sequence IS1999 (truncated or not by IS1R) was located upstream of the bla(OXA-48) and bla(OXA-162) genes in all of the isolates. Pulsed-field gel electrophoresis typing indicated the clonal transmission of an OXA-48-producing Klebsiella pneumoniae strain in two hospitals.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectAnti-Bacterial Agents/pharmacologyeng
dc.subjectHumanseng
dc.subjectEscherichia coli/geneticseng
dc.subjectGermanyeng
dc.subjectPolymerase Chain Reactioneng
dc.subjectHospitalseng
dc.subjectCross Infection/microbiologyeng
dc.subjectBacterial Proteins/geneticseng
dc.subjectMicrobial Sensitivity Testseng
dc.subjectPulsed-Fieldeng
dc.subjectCross Infection/transmissioneng
dc.subjectbeta-Lactamases/biosynthesiseng
dc.subjectBacterial Proteins/biosynthesiseng
dc.subjectbeta-Lactamases/geneticseng
dc.subjectPlasmids/geneticseng
dc.subjectEnterobacteriaceae/drug effectseng
dc.subjectDNA Transposable Elementseng
dc.subjectConjugation Geneticeng
dc.subjectElectrophoresis Geleng
dc.subjectDrug Resistance Multiple Bacterial/geneticseng
dc.subjectEnterobacteriaceae/enzymologyeng
dc.subjectEnterobacteriaceae Infections/microbiologyeng
dc.subjectEnterobacteriaceae Infections/transmissioneng
dc.subjectEscherichia coli/drug effectseng
dc.subject.ddc610 Medizin
dc.titleEmergence of OXA-48-type carbapenemase-producing Enterobacteriaceae in German hospitals
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10027141
dc.identifier.doi10.1128/AAC.05315-11
dc.identifier.doihttp://dx.doi.org/10.25646/1226
local.edoc.container-titleAntimicrobial Agents and Chemotherapy
local.edoc.container-textPfeifer, Y., Schlatterer, K., Engelmann, E., Schiller, R.A., Frangenberg, H.R., Stiewe, D., Holfelder, M., Witte, W., Nordmann, P., Poirel, L. Emergence of OXA-48-type carbapenemase-producing Enterobacteriaceae in German hospitals (2012) Antimicrobial Agents and Chemotherapy, 56 (4), pp. 2125-2128.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://aac.asm.org/content/early/2012/01/25/AAC.05315-11
local.edoc.container-publisher-nameAmerican Society for Microbiology
local.edoc.container-volume56
local.edoc.container-issue4
local.edoc.container-year2012

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