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2011-04-06Zeitschriftenartikel DOI: 10.1128/​JVI.00064-11
Cytomegalovirus e127 protein interacts with the inhibitory CD200 receptor.
dc.contributor.authorFoster-Cuevas, Mildred
dc.contributor.authorWesterholt, Tina
dc.contributor.authorAhmed, Mohamed
dc.contributor.authorBrown, Marion H.
dc.contributor.authorBarclay, A. Neil
dc.contributor.authorVoigt, Sebastian
dc.date.accessioned2018-05-07T16:02:11Z
dc.date.available2018-05-07T16:02:11Z
dc.date.created2012-11-05
dc.date.issued2011-04-06none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/rerbCalexvF7/PDF/21DcMAXaLz8E.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1343
dc.description.abstractCD200 is a cell surface glycoprotein that binds an inhibitory receptor (CD200R) on myeloid cells. CD200 orthologues are present in many species of virus, and we show that the rat cytomegalovirus CD200 orthologue (e127) is expressed at the cell surface on infected cells. It binds the host CD200R with the same affinity as that of the host protein, and thus this protein acts as a close mimic of the host protein and has the potential to downregulate immune responses to the virus.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut
dc.subjectAnimalseng
dc.subjectViral Proteins/metabolismeng
dc.subjectRatseng
dc.subjectViral Proteins/chemistryeng
dc.subjectProtein Bindingeng
dc.subjectFlow Cytometryeng
dc.subjectAntigens CD/chemistryeng
dc.subjectAntigens CD/metabolism*eng
dc.subjectMacrophages Peritoneal/metabolismeng
dc.subjectMuromegalovirus/immunologyeng
dc.subjectMuromegalovirus/metabolismeng
dc.subjectReceptors Cell Surface/metabolismeng
dc.subject.ddc610 Medizin
dc.titleCytomegalovirus e127 protein interacts with the inhibitory CD200 receptor.
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10027754
dc.identifier.doi10.1128/​JVI.00064-11
dc.identifier.doihttp://dx.doi.org/10.25646/1268
local.edoc.container-titleJournal of Virology
local.edoc.container-textMildred Foster-Cuevas, Tina Westerholt, Mohamed Ahmed, Marion H. Brown, A. Neil Barclay, and Sebastian Voigt. Cytomegalovirus e127 Protein Interacts with the Inhibitory CD200 Receptor. (2011) Journal of Virology, 85 (12), pp. 6055–6059.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://jvi.asm.org/content/85/12/6055
local.edoc.container-publisher-nameAmerican Society for Microbiology
local.edoc.container-volume85
local.edoc.container-issue12
local.edoc.container-year2011

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