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2012-11-07Zeitschriftenartikel DOI: 10.1371/journal.pone.0049111
HIV-Prevalence in Tuberculosis Patients in Germany, 2002–2009: An Estimation Based on HIV and Tuberculosis Surveillance Data
dc.contributor.authorFiebig, Lena
dc.contributor.authorKollan, Christian
dc.contributor.authorHauer, Barbara
dc.contributor.authorGunsenheimer-Bartmeyer, Barbara
dc.contributor.authorHeiden, Matthias an der
dc.contributor.authorHaas, Walter
dc.date.accessioned2018-05-07T16:07:39Z
dc.date.available2018-05-07T16:07:39Z
dc.date.created2012-11-27
dc.date.issued2012-11-07none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reR7qSF4JhveI/PDF/27QlhUmn7XEDQ.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1372
dc.description.abstractTuberculosis (TB) and HIV comorbidity is a major challenge in TB prevention and control but difficult to assess in Germany as in other countries, where data confidentiality precludes notifying the HIV status of TB patients. We aimed to estimate the HIV-prevalence in TB patients in Germany, 2002–2009, and to characterize the HIV/TB patients demographically. Data from the long-term observational open multicentre cohort ClinSurv HIV were used to identify incident TB in HIV-positive individuals. We assessed the cohort’s coverage for the nationwide HIV-positive population by contrasting ClinSurv HIV patients under antiretroviral therapy (ART) with national HIV patient numbers derived from ART prescriptions (data by Insight Health; available for 2006–2009). The HIV-prevalence in TB patients was calculated as the number of HIV/TB cases projected for Germany over all culture-positive TB notifications. From 2002 to 2009, 298 of 15,531 HIV-positive patients enrolled in the ClinSurv HIV cohort were diagnosed with TB. A 21% cohort coverage was determined. The annual estimates of the HIV-prevalence in TB patients were on average 4.5% and ranged from 3.5% (95%CI 2.3–5.1%) in 2007 to 6.6% (95%CI 5.0–8.5%) in 2005. The most recent estimate for 2009 was 4.0% (95%CI 2.6–5.9%). The 298 HIV/TB patients were characterized by a male-to-female ratio of 2.1, by a median age of 38 years at TB diagnosis, and by 59% of the patients having a foreign origin, mainly from Subsahara Africa. We provide, to our knowledge, the first estimate of the HIVprevalence in TB patients for Germany by joint evaluation of anonymous HIV and TB surveillance data sources. The identified level of HIV in TB patients approximates available surveillance data from neighbouring countries and indicates a non-negligible HIV/TB burden in Germany. Our estimation approach is valuable for epidemiological monitoring of HIV/TB within the current legal frameworks.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionsepidemiologie
dc.subjectHumanseng
dc.subjectFemaleeng
dc.subjectMaleeng
dc.subjectAdolescenteng
dc.subjectAdulteng
dc.subjectAgedeng
dc.subjectComorbidityeng
dc.subjectGermany/epidemiologyeng
dc.subjectMiddle Agedeng
dc.subjectAnti-HIV Agents/therapeutic useeng
dc.subjectAntitubercular Agents/therapeutic useeng
dc.subjectHIV/pathogenicityeng
dc.subjectHIV Infections/complicationseng
dc.subjectHIV Infections/epidemiologyeng
dc.subjectHIV Infections/virologyeng
dc.subjectHIV Seropositivityeng
dc.subjectPrevalenceeng
dc.subjectTuberculosis/complicationseng
dc.subjectTuberculosis/epidemiologyeng
dc.subjectTuberculosis/virologyeng
dc.subject.ddc610 Medizin
dc.titleHIV-Prevalence in Tuberculosis Patients in Germany, 2002–2009: An Estimation Based on HIV and Tuberculosis Surveillance Data
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10028677
dc.identifier.doi10.1371/journal.pone.0049111
dc.identifier.doihttp://dx.doi.org/10.25646/1297
local.edoc.container-titlePLoS ONE
local.edoc.container-textFiebig L, Kollan C, Hauer B, Gunsenheimer-Bartmeyer B, an der Heiden M, et al. (2012) HIV-Prevalence in Tuberculosis Patients in Germany, 2002–2009: An Estimation Based on HIV and Tuberculosis Surveillance Data. PLoS ONE 7(11): e49111.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0049111
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume7
local.edoc.container-issue11
local.edoc.container-year2012

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