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2010-08-01Zeitschriftenartikel DOI: 10.1097/INF.0b013e3181d743df
Mumps outbreak in the Republic of Moldova, 2007-2008
dc.contributor.authorSchwarz, Norbert G.
dc.contributor.authorBernard, Helen
dc.contributor.authorMelnic, Anatolie
dc.contributor.authorBucov, Victoria
dc.contributor.authorCaterinciuc, Natalia
dc.contributor.authorHeiden, Matthias an der
dc.contributor.authorAndrews, Nick
dc.contributor.authorPebody, Richard
dc.contributor.authorAidyralieva, Chinara
dc.contributor.authorHahné, Susan
dc.date.accessioned2018-05-07T16:13:33Z
dc.date.available2018-05-07T16:13:33Z
dc.date.created2013-02-06
dc.date.issued2010-08-01none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reAPGxFZ0sc6/PDF/27EmAJxzmnJbI.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1404
dc.description.abstractBackground: Moldova experienced a nationwide mumps outbreak between 2007 and 2008. Single-dose monovalent mumps vaccination at 15 to 18 months was introduced in 1983, replaced by a 2-dose MMR schedule at age 1 and 6 to 7 years in 2002. We investigated the outbreak to quantify its extent, explore the role of primary and secondary vaccine failure, and provide control recommendations. Methods: We analyzed national mumps surveillance and vaccination coverage data to estimate vaccine effectiveness (VE) using the screening method. A retrospective cohort study in 5 educational institutions was conducted to determine age-specific attack rates (ARs) and VE. We compared vaccine strain-specific ARs. Isolation and genotyping of mumps virus strains were performed. Results: Of 31,142 cases reported during October 2007 and July 2008, 80% were in 15- to 24-year-olds. Of cases with information (66%), 92% were vaccinated once, 4% twice. One-dose mumps VE estimates based on surveillance data over 1997-2001 declined from 91% (95% CI: 88%-92%) in 2-year-olds to 72% (70%-74%) in 15- to 19-year-olds. In the cohort study (n = 1589), VE was -40% (-120% to 20%) for 1 dose. For 2 doses it was 62% (-43% to 90%) in 13- to 15-year-olds. ARs were higher in individuals vaccinated with Urabe strains (43%) than with Leningrad-Zagreb strains (14%, P < 0.001). Mumps virus genotype G5 was identified. Conclusion: Low effectiveness of single-dose mumps vaccination was the main cause of the outbreak. Waning immunity may have contributed to this. The risk of mumps in 2-dose vaccinees was low. Other countries in which large population groups have receivedeng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionsepidemiologie
dc.subjectAdolescenteng
dc.subjectHumanseng
dc.subjectFemaleeng
dc.subjectDisease Outbreakseng
dc.subjectMaleeng
dc.subjectChildeng
dc.subjectAdulteng
dc.subjectCohort Studieseng
dc.subjectInfanteng
dc.subjectAge Distributioneng
dc.subjectRetrospective Studieseng
dc.subjectYoung Adulteng
dc.subjectChild Preschooleng
dc.subjectVaccination/methodseng
dc.subjectMumps/epidemiologyeng
dc.subjectMumps Vaccine/administration & dosageeng
dc.subjectMumps virus/geneticseng
dc.subjectMumps virus/isolation & purificationeng
dc.subjectVaccination/utilizationeng
dc.subjectMoldova/epidemiologyeng
dc.subjectMumps virus/classificationeng
dc.subject.ddc610 Medizin
dc.titleMumps outbreak in the Republic of Moldova, 2007-2008
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10029328
dc.identifier.doi10.1097/INF.0b013e3181d743df
dc.identifier.doihttp://dx.doi.org/10.25646/1329
local.edoc.container-titlePediatric Infectious Disease Journal
local.edoc.container-textSchwarz, N.G., Bernard, H., Melnic, A., Bucov, V., Caterinciuc, N., An Der Heiden, M., Andrews, N., Pebody, R., Aidyralieva, C., Hahné, S. Mumps outbreak in the Republic of Moldova, 2007-2008 (2010) Pediatric Infectious Disease Journal, 29 (8), pp. 703-706.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://journals.lww.com/pidj/Citation/2010/08000/Mumps_Outbreak_in_the_Republic_of_Moldova,.6.aspx
local.edoc.container-publisher-nameLippincott, Williams & Wilkins
local.edoc.container-volume29
local.edoc.container-issue8
local.edoc.container-year2010

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