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2013-01-14Zeitschriftenartikel DOI: 10.1186/1742-4690-10-7
HIV-1 subtype distribution and its demographic determinants in newly diagnosed patients in Europe suggest highly compartmentalized epidemics
dc.contributor.authorAbecasis, Ana B.
dc.contributor.authorWensing, Annemarie M. J.
dc.contributor.authorParaskevis, Dimitris
dc.contributor.authorVercauteren, Jurgen
dc.contributor.authorTheys, Kristof
dc.contributor.authorVijver, David A. M. C. van de
dc.contributor.authorAlbert, Jan
dc.contributor.authorAsjö, Birgitta
dc.contributor.authorBalotta, Claudia
dc.contributor.authorBeshkov, Danail
dc.contributor.authorCamacho, Ricardo J.
dc.contributor.authorClotet, Bonaventura
dc.contributor.authorGascun, Cillian De
dc.contributor.authorGriskevicius, Algis
dc.contributor.authorGrossman, Zehava
dc.contributor.authorHamouda, Osamah
dc.contributor.authorHorban, Andrzej
dc.contributor.authorKolupajeva, Tatjana
dc.contributor.authorKorn, Klaus
dc.contributor.authorKostrikis, Leon G.
dc.contributor.authorKücherer, Claudia
dc.date.accessioned2018-05-07T16:14:28Z
dc.date.available2018-05-07T16:14:28Z
dc.date.created2013-03-01
dc.date.issued2013-01-14none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reKTEz2dkTg/PDF/223kv0l92ATJs.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1409
dc.description.abstractBackground: Understanding HIV-1 subtype distribution and epidemiology can assist preventive measures and clinical decisions. Sequence variation may affect antiviral drug resistance development, disease progression, evolutionary rates and transmission routes. Results: We investigated the subtype distribution of HIV-1 in Europe and Israel in a representative sample of patients diagnosed between 2002 and 2005 and related it to the demographic data available. 2793 PRO-RT sequences were subtyped either with the REGA Subtyping tool or by a manual procedure that included phylogenetic tree and recombination analysis. The most prevalent subtypes/CRFs in our dataset were subtype B (66.1%), followed by sub-subtype A1 (6.9%), subtype C (6.8%) and CRF02_AG (4.7%). Substantial differences in the proportion of new diagnoses with distinct subtypes were found between European countries: the lowest proportion of subtype B was found in Israel (27.9%) and Portugal (39.2%), while the highest was observed in Poland (96.2%) and Slovenia (93.6%). Other subtypes were significantly more diagnosed in immigrant populations. Subtype B was significantly more diagnosed in men than in women and in MSM > IDUs > heterosexuals. Furthermore, the subtype distribution according to continent of origin of the patients suggests they acquired their infection there or in Europe from compatriots. Conclusions: The association of subtype with demographic parameters suggests highly compartmentalized epidemics, determined by social and behavioural characteristics of the patients.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionsepidemiologie
dc.subjectHumanseng
dc.subjectFemaleeng
dc.subjectMaleeng
dc.subjectBayes Theoremeng
dc.subjectRisk Factorseng
dc.subjectHIV Infections/epidemiologyeng
dc.subjectHIV Infections/virologyeng
dc.subjectEurope/epidemiologyeng
dc.subjectHIV-1/geneticseng
dc.subjectEpidemicseng
dc.subjectHIV-1/classificationeng
dc.subjectRisk-Takingeng
dc.subjectSocial Behavioreng
dc.subjectSocioeconomic Factorseng
dc.subject.ddc610 Medizin
dc.titleHIV-1 subtype distribution and its demographic determinants in newly diagnosed patients in Europe suggest highly compartmentalized epidemics
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10029444
dc.identifier.doi10.1186/1742-4690-10-7
dc.identifier.doihttp://dx.doi.org/10.25646/1334
local.edoc.container-titleRetrovirology
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.retrovirology.com/content/10/1/7
local.edoc.container-publisher-nameBioMedCentral
local.edoc.container-volume10
local.edoc.container-issue7
local.edoc.container-year2013

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