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2012-07-25Zeitschriftenartikel DOI: 10.1128/​JVI.01498-12
Eastern Chimpanzees, but not Bonobos, Represent a Simian Immunodeficiency Virus Reservoir
dc.contributor.authorLi, Yingying
dc.contributor.authorNdjango, Jean-Bosco
dc.contributor.authorLearn, Gerald H.
dc.contributor.authorRamirez, Miguel
dc.contributor.authorKeele, Brandon F.
dc.contributor.authorBibollet-Ruche, Frederic
dc.contributor.authorLiu, Weimin
dc.contributor.authorEaslick, Juliet L.
dc.contributor.authorDecker, Julie M.
dc.contributor.authorRudicell, Rebecca S.
dc.contributor.authorInogwabini, Bila-Isia
dc.contributor.authorAhuka-Mundeke, Steve
dc.contributor.authorLeendertz, Fabian
dc.contributor.authorReynolds, Vernon
dc.contributor.authorMuller, Martin N.
dc.contributor.authorChancellor, Rebecca L.
dc.contributor.authorRundus, Aaron S.
dc.contributor.authorSimmons, Nicole
dc.contributor.authorWorobey, Michael
dc.contributor.authorShaw, George M.
dc.contributor.authorPeeters, Martine
dc.contributor.authorSharp, Paul M.
dc.contributor.authorHahn, Beatrice H.
dc.date.accessioned2018-05-07T16:16:08Z
dc.date.available2018-05-07T16:16:08Z
dc.date.created2013-03-06
dc.date.issued2012-07-25none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/re2AFUST8wJE/PDF/24WputDVSTcQw.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1418
dc.description.abstractChimpanzees in west central Africa (Pan troglodytes troglodytes) are endemically infected with simian immunodeficiency viruses (SIVcpzPtt) that have crossed the species barrier to humans and gorillas on at least five occasions, generating pandemic and nonpandemic forms of human immunodeficiency virus type 1 (HIV-1) as well as gorilla SIV (SIVgor). Chimpanzees in east Africa (Pan troglodytes schweinfurthii) are also infected with SIVcpz; however, their viruses (SIVcpzPts) have never been found in humans. To examine whether this is due to a paucity of natural infections, we used noninvasive methods to screen wild-living eastern chimpanzees in the Democratic Republic of the Congo (DRC), Uganda, and Rwanda. We also screened bonobos (Pan paniscus) in the DRC, a species not previously tested for SIV in the wild. Fecal samples (n = 3,108) were collected at 50 field sites, tested for species and subspecies origin, and screened for SIVcpz antibodies and nucleic acids. Of 2,565 samples from eastern chimpanzees, 323 were antibody positive and 92 contained viral RNA. The antibody-positive samples represented 76 individuals from 19 field sites, all sampled north of the Congo River in an area spanning 250,000 km(2). In this region, SIVcpzPts was common and widespread, with seven field sites exhibiting infection rates of 30% or greater. The overall prevalence of SIVcpzPts infection was 13.4% (95% confidence interval, 10.7% to 16.5%). In contrast, none of the 543 bonobo samples from six sites was antibody positive. All newly identified SIVcpzPts strains clustered in strict accordance to their subspecies origin; however, they exhibited considerable genetic diversity, especially in protein domains known to be under strong host selection pressure. Thus, the absence of SIVcpzPts zoonoses cannot be explained by an insufficient primate reservoir. Instead, greater adaptive hurdles may have prevented the successful colonization of humans by P. t. schweinfurthii viruses.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut
dc.subjectAmino Acid Sequenceeng
dc.subjectHumanseng
dc.subjectMolecular Sequence Dataeng
dc.subjectPhylogenyeng
dc.subjectSequence Homologyeng
dc.subjectAmino Acideng
dc.subjectFemaleeng
dc.subjectMaleeng
dc.subjectAnimalseng
dc.subjectGenetic Variationeng
dc.subjectSimian immunodeficiency virus/geneticseng
dc.subjectSimian immunodeficiency virus/immunologyeng
dc.subjectGenomeeng
dc.subjectPan troglodyteseng
dc.subjectUgandaeng
dc.subjectGeographyeng
dc.subjectSimian Acquired Immunodeficiency Syndrome/virologyeng
dc.subjectAntibodies/chemistryeng
dc.subjectSimian Acquired Immunodeficiency Syndrome/immunologyeng
dc.subjectCD4-Positive T-Lymphocytes/cytologyeng
dc.subjectDemocratic Republic of the Congoeng
dc.subjectLikelihood Functionseng
dc.subjectPan paniscuseng
dc.subjectRwandaeng
dc.subjectVirioneng
dc.subject.ddc610 Medizin
dc.titleEastern Chimpanzees, but not Bonobos, Represent a Simian Immunodeficiency Virus Reservoir
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10029541
dc.identifier.doi10.1128/​JVI.01498-12
dc.identifier.doihttp://dx.doi.org/10.25646/1343
local.edoc.container-titleJournal of Virology
local.edoc.container-textLi, Y., Ndjango, J.-B., Learn, G.H., Ramirez, M.A., Keele, B.F., Bibollet-Ruche, F., Liu, W., Easlick, J.L., Decker, J.M., Rudicell, R.S., Inogwabini, B.-I., Ahuka-Mundeke, S., Leendertz, F.H., Reynolds, V., Muller, M.N., Chancellor, R.L., Rundus, A.S., Simmons, N., Worobey, M., Shaw, G.M., Peeters, M., Sharp, P.M., Hahna, B.H. Eastern chimpanzees, but not bonobos, represent a simian immunodeficiency virus reservoir (2012) Journal of Virology, 86 (19), pp. 10776-10791.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://jvi.asm.org/content/early/2012/07/19/JVI.01498-12
local.edoc.container-publisher-nameAmerican Society for Microbiology
local.edoc.container-volume86
local.edoc.container-issue19
local.edoc.container-year2012

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