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2012-12-20Zeitschriftenartikel DOI: 10.1371/journal.pone.0050882
Treponema pallidum Infection in the Wild Baboons of East Africa: Distribution and Genetic Characterization of the Strains Responsible
dc.contributor.authorHarper, Kristin N.
dc.contributor.authorFyumagwa, Robert D.
dc.contributor.authorHoare, Richard
dc.contributor.authorWambura, Philemon N.
dc.contributor.authorCoppenhaver, Dorian H.
dc.contributor.authorSapolsky, Robert M.
dc.contributor.authorAlberts, Susan C.
dc.contributor.authorTung, Jenny
dc.contributor.authorRogers, Jeffrey
dc.contributor.authorKilewo, Morris
dc.contributor.authorBatamuzi, Emmanuel K.
dc.contributor.authorLeendertz, Fabian
dc.contributor.authorArmelagos, George J.
dc.contributor.authorKnauf, Sascha
dc.date.accessioned2018-05-07T16:18:56Z
dc.date.available2018-05-07T16:18:56Z
dc.date.created2013-03-27
dc.date.issued2012-12-20none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reUDuPIfUAbP6/PDF/29LW3O6DTlJ3M.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1433
dc.description.abstractIt has been known for decades that wild baboons are naturally infected with Treponema pallidum, the bacterium that causes the diseases syphilis (subsp. pallidum), yaws (subsp. pertenue), and bejel (subsp. endemicum) in humans. Recently, a form of T. pallidum infection associated with severe genital lesions has been described in wild baboons at Lake Manyara National Park in Tanzania. In this study, we investigated ten additional sites in Tanzania and Kenya using a combination of macroscopic observation and serology, in order to determine whether the infection was present in each area. In addition, we obtained genetic sequence data from six polymorphic regions using T. pallidum strains collected from baboons at two different Tanzanian sites. We report that lesions consistent with T. pallidum infection were present at four of the five Tanzanian sites examined, and serology was used to confirm treponemal infection at three of these. By contrast, no signs of treponemal infection were observed at the six Kenyan sites, and serology indicated T. pallidum was present at only one of them. A survey of sexually mature baboons at Lake Manyara National Park in 2006 carried out as part of this study indicated that roughly ten percent displayed T. pallidum-associated lesions severe enough to cause major structural damage to the genitalia. Finally, we found that T. pallidum strains from Lake Manyara National Park and Serengeti National Park were genetically distinct, and a phylogeny suggested that baboon strains may have diverged prior to the clade containing human strains. We conclude that T. pallidum infection associated with genital lesions appears to be common in the wild baboons of the regions studied in Tanzania. Further study is needed to elucidate the infection's transmission mode, its associated morbidity and mortality, and the relationship between baboon and human strains.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut
dc.subjectBacterial/geneticseng
dc.subjectBacterial/bloodeng
dc.subjectBacterial/immunologyeng
dc.subjectAnimalseng
dc.subjectHumanseng
dc.subjectFemaleeng
dc.subjectMaleeng
dc.subjectPhylogenyeng
dc.subjectAfrica Eastern/epidemiologyeng
dc.subjectAntibodieseng
dc.subjectDNAeng
dc.subjectEvolution Moleculareng
dc.subjectMonkey Diseases/bloodeng
dc.subjectMonkey Diseases/epidemiologyeng
dc.subjectMonkey Diseases/microbiologyeng
dc.subjectPapio/microbiologyeng
dc.subjectSequence Analysis DNAeng
dc.subjectSpecies Specificityeng
dc.subjectSyphilis/bloodeng
dc.subjectSyphilis/epidemiologyeng
dc.subjectSyphilis/microbiologyeng
dc.subjectSyphilis/veterinaryeng
dc.subjectTreponema pallidum/geneticseng
dc.subjectTreponema pallidum/immunologyeng
dc.subjectTreponema pallidum/physiologyeng
dc.subject.ddc610 Medizin
dc.titleTreponema pallidum Infection in the Wild Baboons of East Africa: Distribution and Genetic Characterization of the Strains Responsible
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10029777
dc.identifier.doi10.1371/journal.pone.0050882
dc.identifier.doihttp://dx.doi.org/10.25646/1358
local.edoc.container-titlePLoS ONE
local.edoc.container-textHarper, K.N., Fyumagwa, R.D., Hoare, R., Wambura, P.N., Coppenhaver, D.H., Sapolsky, R.M., Alberts, S.C., Tung, J., Rogers, J., Kilewo, M., Batamuzi, E.K., Leendertz, F.H., Armelagos, G.J., Knauf, S. Treponema pallidum Infection in the Wild Baboons of East Africa: Distribution and Genetic Characterization of the Strains Responsible (2012) PLoS ONE, 7 (12), art. no. e50882.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0050882
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume7
local.edoc.container-issue12
local.edoc.container-year2012

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