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2013-01-24Zeitschriftenartikel DOI: 10.25646/1360
From theory to practice: molecular strain typing for the clinical and public health setting
dc.contributor.authorGoering, Richard V.
dc.contributor.authorKöck, Robin
dc.contributor.authorGrundmann, Hajo
dc.contributor.authorWerner, Guido
dc.contributor.authorFriedrich, Alexander W.
dc.date.accessioned2018-05-07T16:19:20Z
dc.date.available2018-05-07T16:19:20Z
dc.date.created2013-03-27
dc.date.issued2013-01-24none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/rezPnG2NgAU02/PDF/20RAsnGXu5hkk.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1435
dc.description.abstractThe persistence and transmission of infectious disease is one of the most enduring and daunting concerns in healthcare. Over the years, epidemiological analysis especially of bacterial etiological agents has undergone a remarkable evolutionary metamorphosis. While initially relying on purely phenotypic characterisation, advances in molecular biology have found translational application in a number of approaches to strain typing which commonly centre either on ‘epityping’ (molecular epidemiology) to characterise outbreaks, perform surveillance, and trace evolutionary pathways, or ‘pathotyping’ to compare strains based on the presence or absence of specific virulence or resistance genes. A perspective overview of strain typing is presented here considering the issues surrounding analyses which are employed in the localised clinical setting as well as at a more regional/national public health level. The discussion especially considers the shortcomings inherent in epidemiological analysis: less than full isolate characterisation by the typing method and limitations imposed by the available data, context, and time constraints of the epidemiological investigation (i.e. the available epidemiological window). However, the promises outweigh the pitfalls as one considers the potential for advances in genomic characterisation and information technology to provide an unprecedented aggregate of epidemiological information and analysis.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectHumanseng
dc.subjectDatabases Geneticeng
dc.subjectImage Processing Computer-Assistedeng
dc.subjectMolecular Epidemiology/methodseng
dc.subjectMolecular Typingeng
dc.subjectPublic Healtheng
dc.subjectSequence Analysis/methodseng
dc.subject.ddc610 Medizin
dc.titleFrom theory to practice: molecular strain typing for the clinical and public health setting
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10029799
dc.identifier.doihttp://dx.doi.org/10.25646/1360
local.edoc.container-titleEuroSurveillance
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20383
local.edoc.container-publisher-nameECDC
local.edoc.container-volume18
local.edoc.container-issue4
local.edoc.container-year2013

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