2013-06-01Zeitschriftenartikel DOI: 10.25646/1539
Novel Mycobacterium tuberculosis Complex Isolate from a Wild Chimpanzee
Dabrowski, Piotr Wojtek
Tuberculosis (TB) is caused by gram-positive bacteria known as the Mycobacterium tuberculosis complex (MTBC). MTBC include several human-associated lineages and several variants adapted to domestic and, more rarely, wild animal species. We report an M. tuberculosis strain isolated from a wild chimpanzee in Côte d’Ivoire that was shown by comparative genomic and phylogenomic analyses to belong to a new lineage of MTBC, closer to the human-associated lineage 6 (also known as M. africanum West Africa 2) than to the other classical animal-associated MTBC strains. These results show that the general view of the genetic diversity of MTBC is limited and support the possibility that other MTBC variants exist, particularly in wild mammals in Africa. Exploring this diversity is crucial to the understanding of the biology and evolutionary history of this widespread infectious disease.
Dateien zu dieser Publikation
Anzeige der Publikationen mit ähnlichem Titel, Autor, Urheber und Thema.
2017-07-25ZeitschriftenartikelImmunological recovery in tuberculosis/HIV co-infected patients on antiretroviral therapy: implication for tuberculosis preventive therapy Karo, Basel; Krause, Gérard; Castell, Stefanie; Kollan, Christian; Hamouda, Osamah; Haas, WalterBackground: Understanding the immune response to combination antiretroviral therapy (cART) is essential for a clear approach to tuberculosis (TB) preventive therapy. We investigated the immunological recovery in ...
2011-01-04ZeitschriftenartikelA comparative examination of tuberculosis immigration medical screening programs from selected countries with high immigration and low tuberculosis incidence rates Alvarez, Gonzalo G.; Gushulak, Brian; Rumman, Khaled Abu; Altpeter, Ekkehardt; Chemtob, Daniel; Douglas, Paul; Erkens, Connie; Helbling, Peter; Hamilton, Ingrid; Jones, Jane; Matteelli, Alberto; Paty, Marie-Claire; Posey, Drew L.; Sagebiel, Daniel; Slump, Erika; Tegnell, Anders; Valín, Elena Rodríguez; Winje, Brita Askeland; Ellis, EdwardBackground: Tuberculosis (TB) in migrants is an ongoing challenge in several low TB incidence countries since a large proportion of TB in these countries occurs in migrants from high incidence countries. To meet these ...
2012-11-07ZeitschriftenartikelHIV-Prevalence in Tuberculosis Patients in Germany, 2002–2009: An Estimation Based on HIV and Tuberculosis Surveillance Data Fiebig, Lena; Kollan, Christian; Hauer, Barbara; Gunsenheimer-Bartmeyer, Barbara; Heiden, Matthias an der; Haas, WalterTuberculosis (TB) and HIV comorbidity is a major challenge in TB prevention and control but difficult to assess in Germany as in other countries, where data confidentiality precludes notifying the HIV status of TB patients. ...