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2012-11-21Zeitschriftenartikel DOI: 10.1093/infdis/jis702
Carrier prevalence, secondary household transmission and long-term shedding in two districts during the Escherichia coli O104:H4 outbreak in Germany, 2011
dc.contributor.authorSin, Muna Abu
dc.contributor.authorTakla, Anja
dc.contributor.authorFlieger, Antje
dc.contributor.authorPrager, Rita
dc.contributor.authorFruth, Angelika
dc.contributor.authorTietze, Erhard
dc.contributor.authorFink, Eckhart
dc.contributor.authorKorte, Jutta
dc.contributor.authorSchink, Susanne
dc.contributor.authorHöhle, Michael
dc.contributor.authorEckmanns, Tim
dc.date.accessioned2018-05-07T17:14:21Z
dc.date.available2018-05-07T17:14:21Z
dc.date.created2013-11-28
dc.date.issued2012-11-21none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reiVJF4Wezb8M/PDF/21pJdgxvvy7t2.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1736
dc.description.abstractBackground: From May-July 2011, Germany experienced a large Shiga toxin-producing E. coli (STEC) O104:H4 outbreak. Our objective was to identify the prevalence of STEC O104:H4 carriers in households in highly affected areas, the rate of secondary household transmissions, and the duration of long-term shedding. Methods: In a cross-sectional study, we recruited case and control households to determine STEC household prevalence; we then conducted a prospective cohort study (≥2-persons households with ≥1 case) for rates of household transmission and shedding duration. Results: For part 1, we recruited 57 case households (62 cases and 93 household contacts) and 36 control households (89 household members). We only detected cases in previously known case households and identified 1 possible adult-to-adult household transmission. For part 2, we followed 14 households and 20 carriers. No secondary household transmission was detected in the prospective follow-up. The longest prolonged shedding lasted >7 months, however, median estimated shedding time was 10-14 days (95% CI: 0-33 days). Three carriers showed intermittent shedding. Conclusions: Prevalence of STEC O104:H4 carriers even in highly affected areas appears to be low. Despite prolonged shedding in some patients, secondary adult-to-adult household transmissions seem to be rare events in the post-diarrheal disease phase.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut
dc.subjectHumanseng
dc.subjectFemaleeng
dc.subjectMaleeng
dc.subjectAdulteng
dc.subjectCross-Sectional Studieseng
dc.subjectMiddle Agedeng
dc.subjectYoung Adulteng
dc.subjectPrevalenceeng
dc.subjectDisease Outbreakseng
dc.subjectEscherichia coli Infections/epidemiologyeng
dc.subjectCarrier State/epidemiologyeng
dc.subjectEscherichia coli Infections/transmissioneng
dc.subjectFamily Characteristicseng
dc.subjectHemolytic-Uremic Syndrome/epidemiologyeng
dc.subjectShiga-Toxigenic Escherichia colieng
dc.subject.ddc610 Medizin
dc.titleCarrier prevalence, secondary household transmission and long-term shedding in two districts during the Escherichia coli O104:H4 outbreak in Germany, 2011
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10033849
dc.identifier.doi10.1093/infdis/jis702
dc.identifier.doihttp://dx.doi.org/10.25646/1661
local.edoc.container-titleJournal of Infectious Diseases
local.edoc.container-textSin, M.A., Takla, A., Flieger, A., Prager, R., Fruth, A., Tietze, E., Fink, E., Korte, J., Schink, S., Höhle, M., Eckmanns, T. Carrier prevalence, secondary household transmission, and long-term shedding in 2 districts during the escherichia coli O104:H4 outbreak in Germany, 2011 (2013) Journal of Infectious Diseases, 207 (3), pp. 432-438.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://jid.oxfordjournals.org/content/early/2012/11/20/infdis.jis702
local.edoc.container-publisher-nameOxford University Press
local.edoc.container-volume207
local.edoc.container-issue3
local.edoc.container-year2013

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