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2013-07-01Zeitschriftenartikel DOI: 10.1007/s00103-013-1777-3
Background paper to the recommendation for routine rotavirus vaccination of infants in Germany
dc.contributor.authorKoch, Judith
dc.contributor.authorWiese-Posselt, Miriam
dc.contributor.authorRemschmidt, Cornelius
dc.contributor.authorWichmann, Ole
dc.contributor.authorBertelsmann, H.
dc.contributor.authorGarbe, E.
dc.contributor.authorHengel, Hartmut
dc.contributor.authorMeerpohl, Joerg J.
dc.contributor.authorMarques, Andreas Mas
dc.contributor.authorOppermann, Hanna
dc.contributor.authorHummers-Pradier, E.
dc.contributor.authorKries, Rüdiger von
dc.contributor.authorMertens, Thomas
dc.date.accessioned2018-05-07T17:46:23Z
dc.date.available2018-05-07T17:46:23Z
dc.date.created2014-07-02
dc.date.issued2013-07-01none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/rew0v6kswQB7o/PDF/22qKUo3MxSuLs.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1910
dc.description.abstractTwo rotavirus (RV) vaccines were introduced to the European market in 2006. To support the decision-making process of the German Standing Committee on Vaccination ("Ständige Impfkommission", STIKO) regarding adoption of routine RV vaccination into the national vaccination schedule in Germany relevant scientific background was reviewed. According to STIKO’s Standard Operating Procedures for the development of evidence-based vaccination recommendations, a set of key questions was addressed and systematic reviews were performed with a focus on the efficacy, effectiveness, impact and safety of RV vaccines. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology was applied to assess the quality of available evidence. Data from 5 randomized controlled trials demonstrated a high efficacy of RV vaccines in preventing severe RV-associated gastroenteritis (91%) and hospitalization (92%) in settings comparable to Germany. Post-marketing observational studies confirmed these findings. In several countries, impact studies suggest that age groups not eligible for vaccination might also benefit from herd effects and demonstrated a decrease in the number of nosocomial RV infections after RV vaccine introduction. The vaccines were considered safe, except for a slightly increased risk of intussusception shortly after the first dose, corresponding to 1-2 additional cases per 100,000 infants vaccinated (relative risk =1.21, 95% confidence interval [CI] 0.68-2.14). RV case-fatality is extremely low in Germany. However, RV incidence among children agedeng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionsepidemiologie
dc.subjectGermanyeng
dc.subjectHumanseng
dc.subjectFemaleeng
dc.subjectMaleeng
dc.subjectInfanteng
dc.subjectInfant Newborneng
dc.subjectMass Vaccination/standardseng
dc.subjectPractice Guidelines as Topiceng
dc.subjectRotavirus Infections/prevention & controleng
dc.subjectRotavirus Vaccines/standardseng
dc.subjectRotavirus Vaccines/therapeutic useeng
dc.subject.ddc610 Medizin
dc.titleBackground paper to the recommendation for routine rotavirus vaccination of infants in Germany
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10036850
dc.identifier.doi10.1007/s00103-013-1777-3
dc.identifier.doihttp://dx.doi.org/10.25646/1835
local.edoc.container-titleBundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://link.springer.com/article/10.1007/s00103-013-1777-3
local.edoc.container-publisher-nameSpringer
local.edoc.container-volume56
local.edoc.container-issue7
local.edoc.container-year2013

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