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2014-08-22Zeitschriftenartikel DOI: 10.1371/journal.pone.0104474
Estimating Trends in the Proportion of Transmitted and Acquired HIV Drug Resistance in a Long Term Observational Cohort in Germany
dc.contributor.authorSchmidt, Daniel
dc.contributor.authorKollan, Christian
dc.contributor.authorFätkenheuer, Gerd
dc.contributor.authorSchülter, Eugen
dc.contributor.authorStellbrink, Hans-Jürgen
dc.contributor.authorNoah, Christian
dc.contributor.authorJensen, Björn-Erik Ole
dc.contributor.authorStoll, Matthias
dc.contributor.authorBogner, Johannes R.
dc.contributor.authorEberle, Josef
dc.contributor.authorMeixenberger, Karolin
dc.contributor.authorKücherer, Claudia
dc.contributor.authorHamouda, Osamah
dc.contributor.authorBartmeyer, Barbara
dc.date.accessioned2018-05-07T17:52:45Z
dc.date.available2018-05-07T17:52:45Z
dc.date.created2014-09-03
dc.date.issued2014-08-22none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/rehGo2FWRgXJE/PDF/27cJooDWRv1sA.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1944
dc.description.abstractObjective: We assessed trends in the proportion of transmitted (TDR) and acquired (ADR) HIV drug resistance and associated mutations between 2001 and 2011 in the German ClinSurv-HIV Drug Resistance Study. Method: The German ClinSurv-HIV Drug Resistance Study is a subset of the German ClinSurv-HIV Cohort. For the ClinSurv-HIV Drug Resistance Study all available sequences isolated from patients in five study centres of the long term observational ClinSurv-HIV Cohort were included. TDR was estimated using the first viral sequence of antiretroviral treatment (ART) naïve patients. One HIV sequence/patient/year of ART experienced patients was considered to estimate the proportion of ADR. Trends in the proportion of HIV drug resistance were calculated by logistic regression. Results: 9,528 patients were included into the analysis. HIV-sequences of antiretroviral naïve and treatment experienced patients were available from 34% (3,267/9,528) of patients. The proportion of TDR over time was stable at 10.4% (95% CI 9.1–11.8; p for trend = 0.6; 2001–2011). The proportion of ADR among all treated patients was 16%, whereas it was high among those with available HIV genotypic resistance test (64%; 1,310/2,049 sequences; 95% CI 62–66) but declined significantly over time (OR 0.8; 95% CI 0.77–0.83; p for trendeng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectGermanyeng
dc.subjectHumanseng
dc.subjectFemaleeng
dc.subjectMaleeng
dc.subjectAdulteng
dc.subjectRisk Factorseng
dc.subjectCohort Studieseng
dc.subjectAnti-HIV Agents/therapeutic useeng
dc.subjectHIV Infections/virologyeng
dc.subjectGenotypeeng
dc.subjectHIV-1/geneticseng
dc.subjectMutationeng
dc.subjectDrug Resistance Viraleng
dc.subjectHIV Infections/drug therapyeng
dc.subjectHIV-1/drug effectseng
dc.subjectViral Loadeng
dc.subjectAntiretroviral Therapy Highly Activeeng
dc.subjectHIV Infections/transmissioneng
dc.subjectAnti-HIV Agents/pharmacologyeng
dc.subject.ddc610 Medizin
dc.titleEstimating Trends in the Proportion of Transmitted and Acquired HIV Drug Resistance in a Long Term Observational Cohort in Germany
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10037357
dc.identifier.doi10.1371/journal.pone.0104474
dc.identifier.doihttp://dx.doi.org/10.25646/1869
local.edoc.container-titlePLoS ONE
local.edoc.container-textSchmidt D, Kollan C, Fätkenheuer G, Schülter E, Stellbrink H-J, et al. (2014) Estimating Trends in the Proportion of Transmitted and Acquired HIV Drug Resistance in a Long Term Observational Cohort in Germany. PLoS ONE 9(8): e104474.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0104474
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume9
local.edoc.container-issue8
local.edoc.container-year2014

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