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2015-01-23Zeitschriftenartikel DOI: 10.1186/s12879-015-0754-x
Soluble MICB protein levels and platelet counts during hepatitis B virus infection and response to hepatocellular carcinoma treatment
Tong, Hoang Van
Song, Le Huu
Hoan, Nghiem Xuan
Cuong, Bui Khac
Sy, Bui Tien
Son, Ho Anh
Quyet, Do
Binh, Vu Quoc
Kremsner, Peter G.
Bock, Thomas
Velavan, Thirumalaisamy P.
Toan, Nguyen Linh
Background: The human major histocompatibility complex class I polypeptide-related sequence B (MICB) is a protein that modulates the NK and T cell activation through the NKG2D receptor and is related to several diseases including cancer. Methods: The study investigated the prognostic role of soluble MICB (sMICB) protein in the progression of HBV-related liver diseases and to HBV-related HCC treatment. The sMICB serum levels were measured in 266 chronic HBV-infected Vietnamese patients and in healthy controls, and correlated with clinical and laboratory parameters and with therapeutic interventions for HBV-related HCC. Results: Significant differences in both clinical and laboratory parameters were observed among the patient groups with different stages of hepatitis. The platelet counts were significantly decreased with disease progression (P 
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DOI
10.1186/s12879-015-0754-x
Permanent URL
https://doi.org/10.1186/s12879-015-0754-x
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<a href="https://doi.org/10.1186/s12879-015-0754-x">https://doi.org/10.1186/s12879-015-0754-x</a>