2015-03-12Zeitschriftenartikel DOI: 10.25646/1956
Impact of 10- and 13-valent pneumococcal conjugate vaccines on incidence of invasive pneumococcal disease in children aged under 16 years in Germany, 2009 to 2012
Linden, M. van der
Kries, Rüdiger von
We assessed the impact of 10-valent and 13-valent pneumococcal vaccines (PCV10 and PCV13), which were introduced in Germany in 2009, on the incidence of meningitis and non-meningitis invasive pneumococcal disease (IPD) in children aged under 16 years in a population previously vaccinated with a seven-valent vaccine (PCV7). Surveillance of IPD (isolation of Streptococcus pneumonia from a normally sterile body site) is based on data from two independent reporting sources: hospitals and laboratories. IPD incidence was estimated by capture–recapture analysis. Incidence rate ratios (IRRs) were calculated for 2009 and 2012, thus comparing pre- and post-PCV10 and PCV13 data. IPD incidence caused by serotypes included in PCV13 decreased in all age and diagnosis groups. A rise in non-vaccine serotype incidence was seen only in children aged under two years. The overall impact varied by age group and infection site: for meningitis IPD in children aged under 2, 2–4 and 5–15 years, incidence changed by 3% (95% CI: −31 to 52), −60% (95% CI: −81 to −17) and −9% (95% CI: −46 to 53), respectively. A more pronounced incidence reduction was observed for non-meningitis IPD: −30% (95% CI: −46 to −7), −39% (95% CI: −54 to −20) and −83% (95% CI: −89 to −73) in children aged under 2, 2–4 and 5–15 years, respectively. A higher tropism of the additional serotypes for non-meningitis IPD may be a potential explanation. The heterogeneous findings emphasise the need for rigorous surveillance.
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