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2015-05-21Zeitschriftenartikel DOI: 10.3389/fmicb.2015.00518
Human seroprevalence indicating hantavirus infections in tropical rainforests of Côte d’Ivoire and Democratic Republic of Congo
dc.contributor.authorWitkowski, Peter T.
dc.contributor.authorLeendertz, Siv Aina J.
dc.contributor.authorAuste, Brita
dc.contributor.authorAkoua-Koffi, Chantal
dc.contributor.authorSchubert, Grit
dc.contributor.authorKlempa, Boris
dc.contributor.authorMuyembe-Tamfum, Jean-Jacques
dc.contributor.authorKarhemere, Stomy
dc.contributor.authorLeendertz, Fabian
dc.contributor.authorKrüger, Detlev H.
dc.date.accessioned2018-05-07T18:17:53Z
dc.date.available2018-05-07T18:17:53Z
dc.date.created2015-06-30
dc.date.issued2015-05-21none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reW6txuC9ZdZs/PDF/26YPClzXsE5yE.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2079
dc.description.abstractHantaviruses are members of the Bunyaviridae family carried by small mammals and causing human hemorrhagic fevers worldwide. In Western Africa, where a variety of hemorrhagic fever viruses occurs, indigenous hantaviruses have been molecularly found in animal reservoirs such as rodents, shrews, and bats since 2006. To investigate the human contact to hantaviruses carried by these hosts and to assess the public health relevance of hantaviruses for humans living in the tropical rainforest regions of Western and Central Africa, we performed a cross-sectional seroprevalence study in the region of Taï National Park in Côte d’Ivoire and the Bandundu region near the Salonga National Park in the Democratic Republic (DR) of Congo. Serum samples were initially screened with enzyme-linked immunosorbent assays using nucleoproteins of several hantaviruses as diagnostic antigens. Positive results were confirmed by Western blotting and immunofluorescence testing. Seroprevalence rates of 3.9% (27/687) and 2.4% (7/295), respectively, were found in the investigated regions in Côte d’Ivoire and the DR Congo. In Côte d’Ivoire, this value was significantly higher than the seroprevalence rates previously reported from the neighboring country Guinea as well as from South Africa. Our study indicates an exposure of humans to hantaviruses in West and Central African tropical rainforest areas. In order to pinpoint the possible existence and frequency of clinical disease caused by hantaviruses in this region of the world, systematic investigations of patients with fever and renal or respiratory symptoms are required.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut
dc.subjecthantaviruseng
dc.subjectAfricaeng
dc.subjectseroprevalenceeng
dc.subjectCôte d’Ivoireeng
dc.subjectDemocratic Republic of Congoeng
dc.subjecttropical rain foresteng
dc.subject.ddc610 Medizin
dc.titleHuman seroprevalence indicating hantavirus infections in tropical rainforests of Côte d’Ivoire and Democratic Republic of Congo
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10039791
dc.identifier.doi10.3389/fmicb.2015.00518
dc.identifier.doihttp://dx.doi.org/10.25646/2004
local.edoc.container-titleFrontiers in Microbiology
local.edoc.container-textWitkowski PT, Leendertz SAJ, Auste B, Akoua-Koffi C, Schubert G, Klempa B, Muyembe-Tamfum J-J, Karhemere S, Leendertz FH and Krüger DH (2015) Human seroprevalence indicating hantavirus infections in tropical rainforests of Côte d’Ivoire and Democratic Republic of Congo. Front. Microbiol. 6:518.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://journal.frontiersin.org/article/10.3389/fmicb.2015.00518/
local.edoc.container-publisher-nameFrontiers Media
local.edoc.container-volume6
local.edoc.container-year2015

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