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2016-06-02Zeitschriftenartikel DOI: 10.1016/j.meegid.2016.05.041
The global spread of HIV-1 subtype B epidemic
dc.contributor.authorMagiorkinis, Gkikas
dc.contributor.authorAngelis, Konstantinos
dc.contributor.authorMamais, Ioannis
dc.contributor.authorKatzourakis, Aris
dc.contributor.authorHatzakis, Angelos
dc.contributor.authorAlbert, Jan
dc.contributor.authorLawyer, Glenn
dc.contributor.authorHamouda, Osamah
dc.contributor.authorStruck, Daniel
dc.contributor.authorVercauteren, Jurgen
dc.contributor.authorWensing, Annemarie
dc.contributor.authorAlexiev, Ivailo
dc.contributor.authorÅsjö, Birgitta
dc.contributor.authorBalotta, Claudia
dc.contributor.authorGomes, Perpétua
dc.contributor.authorCamacho, Ricardo J.
dc.contributor.authorCoughlan, Suzie
dc.contributor.authorGriskevicius, Algirdas
dc.contributor.authorGrossman, Zehava
dc.contributor.authorHorban, Anders
dc.contributor.authorKostrikis, Leondios G.
dc.contributor.authorLepej, Snjezana J.
dc.contributor.authorLiitsola, Kirsi
dc.contributor.authorLinka, Marek
dc.contributor.authorNielsen, Claus
dc.date.accessioned2018-05-07T19:11:06Z
dc.date.available2018-05-07T19:11:06Z
dc.date.created2016-08-01
dc.date.issued2016-06-02none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/rebTHPaQqQg/PDF/21aFW7GOt1bYE.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2368
dc.description.abstractHuman immunodeficiency virus type 1 (HIV-1) was discovered in the early 1980s when the virus had already established a pandemic. For at least three decades the epidemic in the Western World has been dominated by subtype B infections, as part of a sub-epidemic that traveled from Africa through Haiti to United States. However, the pattern of the subsequent spread still remains poorly understood. Here we analyze a large dataset of globally representative HIV-1 subtype B strains to map their spread around the world over the last 50 years and describe significant spread patterns. We show that subtype B travelled from North America to Western Europe in different occasions, while Central/Eastern Europe remained isolated for the most part of the early epidemic. Looking with more detail in European countries we see that the United Kingdom, France and Switzerland exchanged viral isolates with non-European countries than with European ones. The observed pattern is likely to mirror geopolitical landmarks in the post-World War II era, namely the rise and the fall of the Iron Curtain and the European colonialism. In conclusion, HIV-1 spread through specific migration routes which are consistent with geopolitical factors that affected human activities during the last 50 years, such as migration, tourism and trade. Our findings support the argument that epidemic control policies should be global and incorporate political and socioeconomic factors.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionsepidemiologie
dc.subjectPhylogeographyeng
dc.subjectHIV-1eng
dc.subjectSubtype Beng
dc.subjectMigration patterneng
dc.subjectMigrationeng
dc.subject.ddc610 Medizin
dc.titleThe global spread of HIV-1 subtype B epidemic
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10045996
dc.identifier.doi10.1016/j.meegid.2016.05.041
dc.identifier.doihttp://dx.doi.org/10.25646/2293
local.edoc.container-titleInfection, Genetics and Evolution
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.sciencedirect.com/science/article/pii/S1567134816302234
local.edoc.container-publisher-nameElsevier
local.edoc.container-volume46
local.edoc.container-year2016

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