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2016-09-01Zeitschriftenartikel DOI: 10.1186/s13099-016-0122-4
Does antibiotic resistance impair plasma susceptibility of multi-drug resistant clinical isolates of enterococci in vitro?
dc.contributor.authorNapp, Matthias
dc.contributor.authorPodewils, Sebastian von
dc.contributor.authorKlare, Ingo
dc.contributor.authorHaase, Hermann
dc.contributor.authorKasch, Richard
dc.contributor.authorGümbel, Denis
dc.contributor.authorEkkernkamp, Axel
dc.contributor.authorJünger, Michael
dc.contributor.authorDaeschlein, Georg
dc.date.accessioned2018-05-07T19:18:54Z
dc.date.available2018-05-07T19:18:54Z
dc.date.created2016-09-09
dc.date.issued2016-09-01none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reZ9C95yXa6UA/PDF/24V5nhWg9QIaM.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2411
dc.description.abstractBackground: Cold atmospheric plasma could constitute an alternative against multi-drug resistant pathogens. Susceptibility of enterococci to cold atmospheric plasma was investigated in vitro. Methods: 39 clinical isolates of enterococci were grouped dependent on the most important resistance patterns and treated on agar using dielectric barrier discharge plasma. These included enterococci with combined vancomycin- and high-level gentamicin resistance, high-level resistance to gentamicin (HLGR) only, vancomycin resistance alone (VRE), and enterococci susceptible to both. Susceptibility to cold atmospheric plasma was evaluated based on the zones of inhibition and examined in terms of the enterococcal group and the “degree” of drug resistance. Results: Cold atmospheric plasma treatment killed all groups. Comparison of VRE and HLGR strains with non-VRE and non-HLGR isolates concerning zones of inhibition revealed that enterococci with special resistance patterns (VRE and HLGR) showed significantly smaller zones of inhibition than the sensitive ones. The mean of all isolates, irrespective of belonging to groups, showed smaller zones of inhibition with increasing “degree” of drug resistance. Conclusions: Cold atmospheric plasma treatment killed all isolates of enterococci, but its efficacy depended on the “degree” of drug resistance and on membership in special resistance groups with particular clinical-outbreak importance. However, a possible role of the different genetic lineages, which might be prone to acquiring more or less resistance phenotypes, may also play a role in this context.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectDielectric barrier discharge plasma (DBD)eng
dc.subjectCold atmospheric plasma (CAP)eng
dc.subjectAntimicrobial efficacyeng
dc.subjectPlasma susceptibilityeng
dc.subjectPlasma medicineeng
dc.subjectVancomycin-resistant enterococcieng
dc.subjectGentamicin-resistant enterococcieng
dc.subject.ddc610 Medizin
dc.titleDoes antibiotic resistance impair plasma susceptibility of multi-drug resistant clinical isolates of enterococci in vitro?
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10046763
dc.identifier.doi10.1186/s13099-016-0122-4
dc.identifier.doihttp://dx.doi.org/10.25646/2336
local.edoc.container-titleGut Pathogens
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://gutpathogens.biomedcentral.com/articles/10.1186/s13099-016-0122-4
local.edoc.container-publisher-nameBioMedCentral
local.edoc.container-volume8
local.edoc.container-issue41
local.edoc.container-year2016

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