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2017-01-13Zeitschriftenartikel DOI: 10.1038/srep40680
Molecular phylogeny of a novel human adenovirus type 8 strain causing a prolonged, multi-state keratoconjunctivitis epidemic in Germany
dc.contributor.authorHage, Elias
dc.contributor.authorEspelage, Werner
dc.contributor.authorEckmanns, Tim
dc.contributor.authorLamson, Daryl M.
dc.contributor.authorPantó, Laura
dc.contributor.authorGanzenmueller, Tina
dc.contributor.authorHeim, Albert
dc.date.accessioned2018-05-07T19:41:20Z
dc.date.available2018-05-07T19:41:20Z
dc.date.created2017-01-27
dc.date.issued2017-01-13none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reWSZjtvj1TY/PDF/29WhDNO6wEEzQ.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2532
dc.description.abstractThe German infectious disease surveillance system revealed an increase of epidemic keratoconjunctivitis (EKC) from an average of 320 cases/year (2001 to 2010) up to 2146 and 1986 cases in 2012 and 2013, respectively. From November 2011 until December 2013 (epidemic period) 85% of typed isolates were human adenovirus type 8 (HAdV-D8), whereas only low level circulation (19%) of HAdV-D8 was observed outside the epidemic period. In order to investigate whether a novel monophyletic HAdV-D8 strain prevailed during the epidemic period, complete genomic sequences of 23 HAdV-D8 isolates were generated by deep sequencing and analyzed phylogenetically. For comparison, eight HAdV-D8 isolates from outside the epidemic period were sequenced. HAdV-D8 isolates of the epidemic period had a very high sequence identity of at least 99.9% and formed a monophyletic cluster with two subclusters. A single outlier was closely related to HAdV-D8 strains isolated prior to the epidemic period. Circulation of the epidemic strain was detected as early as 2010 but not after the epidemic period in 2014. In conclusion, molecular phylogeny of complete genomic sequences proved a monophyletic HAdV-D8 epidemic. However, co-circulation of other HAdV types as well as better reporting may have contributed to the huge increase of reported cases.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionsepidemiologie
dc.subject.ddc610 Medizin
dc.titleMolecular phylogeny of a novel human adenovirus type 8 strain causing a prolonged, multi-state keratoconjunctivitis epidemic in Germany
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10050956
dc.identifier.doi10.1038/srep40680
dc.identifier.doihttp://dx.doi.org/10.25646/2457
local.edoc.container-titleScientific Reports
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.nature.com/articles/srep40680
local.edoc.container-publisher-nameNature Publishing Group
local.edoc.container-volume7
local.edoc.container-issue40680
local.edoc.container-year2017

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