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2017-01-12Zeitschriftenartikel DOI: 10.2807/1560-7917.ES.2017.22.2.30436
National molecular surveillance of recently acquired HIV infections in Germany, 2013 to 2014
dc.contributor.authorHauser, Andrea
dc.contributor.authorHofmann, Alexandra
dc.contributor.authorHanke, Kirsten
dc.contributor.authorBremer, Viviane
dc.contributor.authorBartmeyer, Barbara
dc.contributor.authorKücherer, Claudia
dc.contributor.authorBannert, Norbert
dc.date.accessioned2018-05-07T19:43:00Z
dc.date.available2018-05-07T19:43:00Z
dc.date.created2017-02-07
dc.date.issued2017-01-12none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/reVycz0ZIutZg/PDF/23mwtFwWpqEqE.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2541
dc.description.abstractTo enable an up-to-date molecular analysis of human immunodeficiency virus (HIV) genotypes circulating in Germany we have established a surveillance system based on recently acquired HIV infections. New HIV infections are reported to the Robert Koch Institute as a statutory duty for anonymous notification. In 2013 and 2014, a dried serum spot (DSS) sample was received from 6,371 newly diagnosed HIV-cases; their analysis suggested that 1,797 samples originated from a recent infection. Of these, 809 were successfully genotyped in the pol region to identify transmitted drug resistance (TDR) mutations and to determine the HIV-1 subtype. Total TDR was 10.8%, comprising 4.3% with mono-resistance to nucleoside reverse transcriptase inhibitors (NRTIs), 2.6% to non-NRTIs, 3.0% to protease inhibitors and 0.6% and 0.2%, respectively, with dual- and triple-class resistances. HIV-1 subtype B was most prevalent with 77.0%. Non-B infections were identified more often in men and women with heterosexual transmission compared with intravenous drug users or men who have sex with men (79% and 76%, 33%, 12%; all p eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subject.ddc610 Medizin
dc.titleNational molecular surveillance of recently acquired HIV infections in Germany, 2013 to 2014
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10051058
dc.identifier.doi10.2807/1560-7917.ES.2017.22.2.30436
dc.identifier.doihttp://dx.doi.org/10.25646/2466
local.edoc.container-titleEuroSurveillance
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=22683
local.edoc.container-publisher-nameECDC
local.edoc.container-volume22
local.edoc.container-issue2
local.edoc.container-year2017

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