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2017-04-12Zeitschriftenartikel DOI: 10.1371/journal.pone.0175304
Prevalence and genotype distribution of hepatitis delta virus among chronic hepatitis B carriers in Central Vietnam
dc.contributor.authorNguyen, Hung Minh
dc.contributor.authorSy, Bui Tien
dc.contributor.authorTrung, Nguyen Thanh
dc.contributor.authorHoan, Nghiem Xuan
dc.contributor.authorWedemeyer, Heiner
dc.contributor.authorVelavan, Thirumalaisamy P.
dc.contributor.authorBock, Thomas
dc.date.accessioned2018-05-07T19:57:17Z
dc.date.available2018-05-07T19:57:17Z
dc.date.created2017-04-20
dc.date.issued2017-04-12none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/renVxMIZOkfM2/PDF/22cAkwRonUJZ2.pdf
dc.identifier.urihttp://edoc.rki.de/176904/2618
dc.description.abstractHepatitis D virus (HDV) infection plays an important role in liver diseases. However, the molecular epidemiology and impact of HDV infection in chronic hepatitis B (CHB) remain uncertain in Vietnam. This cross-sectional study aimed to investigate the prevalence and genotype distribution of HDV among HBsAg-positive patients in Central Vietnam. 250 CHB patients were tested for HDV using newly established HDV-specific RT-PCR techniques. HDV genotypes were determined by direct sequencing. Of the 250 patients 25 (10%) had detectable copies of HDV viral RNA. HDV-2 was predominant (20/25; 80%) followed by HDV-1 (5/25; 20%). Proven HDV genotypes share the Asian nomenclature. Chronic hepatitis B patients with concomitant HDV-1 showed higher HBV loads as compared to HDV-2 infected patients [median log10 (HBV-DNA copies/ml): 8.5 vs. 4.4, P = 0.036]. Our findings indicate that HDV infection is highly prevalent and HDV-2 is predominant in Central Vietnam. The data will add new information to the management of HBsAg-positive patients in a highly HBV endemic region to in- or exclude HDV infection in terms of diagnostic and treatment options.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subject.ddc610 Medizin
dc.titlePrevalence and genotype distribution of hepatitis delta virus among chronic hepatitis B carriers in Central Vietnam
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10052277
dc.identifier.doi10.1371/journal.pone.0175304
dc.identifier.doihttp://dx.doi.org/10.25646/2543
local.edoc.container-titlePLoS ONE
local.edoc.anmerkung‘European Union (EU)’ and ‘Horizon 2020’
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0175304
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume12
local.edoc.container-issue4
local.edoc.container-year2017

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