Evaluating the Impact of Functional Genetic Variation on HIV-1 Control
dc.contributor.author | McLaren, Paul J. | |
dc.contributor.author | Pulit, Sara L. | |
dc.contributor.author | Gurdasani, Deepti | |
dc.contributor.author | Bartha, Istvan | |
dc.contributor.author | Shea, Patrick R. | |
dc.contributor.author | Pomilla, Cristina | |
dc.contributor.author | Gupta, Namrata | |
dc.contributor.author | Gkrania-Klotsas, Effrossyni | |
dc.contributor.author | Young, Elizabeth H. | |
dc.contributor.author | Bannert, Norbert | |
dc.contributor.author | Amo, Julia Del | |
dc.contributor.author | Gill, M. John | |
dc.contributor.author | Gilmour, Jill | |
dc.contributor.author | Kellam, Paul | |
dc.contributor.author | Kelleher, Anthony D. | |
dc.contributor.author | Sönnerborg, Anders | |
dc.contributor.author | Zangerle, Robert | |
dc.contributor.author | Post, Frank A. | |
dc.contributor.author | Fisher, Martin | |
dc.contributor.author | Haas, David W. | |
dc.contributor.author | Walker, Bruce D. | |
dc.contributor.author | Porter, Kholoud | |
dc.contributor.author | Goldstein, David B. | |
dc.contributor.author | Sandhu, Manjinder S. | |
dc.contributor.author | Fellay, Jacques | |
dc.date.accessioned | 2018-05-07T21:06:48Z | |
dc.date.available | 2018-05-07T21:06:48Z | |
dc.date.created | 2018-02-16 | |
dc.date.issued | 2017-11-27 | none |
dc.identifier.other | http://edoc.rki.de/oa/articles/reeEz1CIxsjEY/PDF/22kyQt0TDpiQ.pdf | |
dc.identifier.uri | http://edoc.rki.de/176904/2991 | |
dc.description.abstract | Background: Previous genetic association studies of human immunodeficiency virus-1 (HIV-1) progression have focused on common human genetic variation ascertained through genome-wide genotyping. Methods: We sought to systematically assess the full spectrum of functional variation in protein coding gene regions on HIV-1 progression through exome sequencing of 1327 individuals. Genetic variants were tested individually and in aggregate across genes and gene sets for an influence on HIV-1 viral load. Results: Multiple single variants within the major histocompatibility complex (MHC) region were observed to be strongly associated with HIV-1 outcome, consistent with the known impact of classical HLA alleles. However, no single variant or gene located outside of the MHC region was significantly associated with HIV progression. Set-based association testing focusing on genes identified as being essential for HIV replication in genome-wide small interfering RNA (siRNA) and clustered regularly interspaced short palindromic repeats (CRISPR) studies did not reveal any novel associations. Conclusions: These results suggest that exonic variants with large effect sizes are unlikely to have a major contribution to host control of HIV infection. | eng |
dc.language.iso | ger | |
dc.publisher | Robert Koch-Institut, Infektionskrankheiten / Erreger | |
dc.subject | Single Nucleotide | eng |
dc.subject | Humans | eng |
dc.subject | Female | eng |
dc.subject | Male | eng |
dc.subject | Adult | eng |
dc.subject | Middle Aged | eng |
dc.subject | Genetic Predisposition to Disease | eng |
dc.subject | HIV Infections/virology | eng |
dc.subject | Genotype | eng |
dc.subject | HIV-1/genetics | eng |
dc.subject | Genetic Variation | eng |
dc.subject | Polymorphism | eng |
dc.subject | HIV Infections/genetics | eng |
dc.subject | Host-Pathogen Interactions/genetics | eng |
dc.subject | Viral Load/genetics | eng |
dc.subject | Whole Exome Sequencing | eng |
dc.subject.ddc | 610 Medizin | |
dc.title | Evaluating the Impact of Functional Genetic Variation on HIV-1 Control | |
dc.type | periodicalPart | |
dc.identifier.urn | urn:nbn:de:0257-10057592 | |
dc.identifier.doi | 10.1093/infdis/jix470 | |
dc.identifier.doi | http://dx.doi.org/10.25646/2916 | |
local.edoc.container-title | Journal of Infectious Diseases | |
local.edoc.anmerkung | ‘European Union (EU)’ and ‘Horizon 2020’ | |
local.edoc.fp-subtype | Artikel | |
local.edoc.type-name | Zeitschriftenartikel | |
local.edoc.container-type | periodical | |
local.edoc.container-type-name | Zeitschrift | |
local.edoc.container-url | https://academic.oup.com/jid/article/216/9/1063/4110184 | |
local.edoc.container-publisher-name | Oxford University Press | |
local.edoc.container-volume | 216 | |
local.edoc.container-issue | 9 | |
local.edoc.container-year | 2017 |