Browsing Artikel in Fachzeitschriften by Author "Daus, Martin L."

Now showing items 1-7 of 7

2012-01-01Zeitschriftenartikel

Chronic wasting disease: Fingerprinting the culprit in risk assessments

Daus, Martin L.; Beekes, Michael

Transmissible spongiform encephalopathies (prion diseases) in animals may be associated with a zoonotic risk potential for humans as shown by the occurrence of variant Creutzfeldt-Jakob disease in the wake of the bovine ...
2014-10-25Zeitschriftenartikel

Decontamination of medical devices from pathological amyloid-β-, tau- and α-synuclein aggregates

Thomzig, Achim; Wagenführ, Katja; Daus, Martin L.; Joncic, Marion; Schulz-Schaeffer, Walter J.; Thanheiser, Marc; Mielke, Martin; Beekes, Michael
2016-01-04Zeitschriftenartikel

Disease Transmission by Misfolded Prion-Protein Isoforms, Prion-Like Amyloids, Functional Amyloids and the Central Dogma

Daus, Martin L.

In 1982, the term “prions” (proteinaceous infectious particles) was coined to specify a new principle of infection. A misfolded isoform of a cellular protein has been described as the causative agent of a fatal neurodegenerative ...
2011-04-01Zeitschriftenartikel

Presence and seeding activity of pathological prion protein (PrP(TSE)) in skeletal muscles of white-tailed deer infected with chronic wasting disease.

Daus, Martin L.; Breyer, Johanna; Wagenführ, Katja; Wemheuer, Wiebke M.; Thomzig, Achim; Schulz-Schaeffer, Walter; Beekes, Michael

Chronic wasting disease (CWD) is a contagious, rapidly spreading transmissible spongiform encephalopathy (TSE), or prion disease, occurring in cervids such as white tailed-deer (WTD), mule deer or elk in North America. ...
2011-05-27Zeitschriftenartikel

Quantitative detection and biological propagation of scrapie seeding activity in vitro facilitate use of prions as model pathogens for disinfection.

Pritzkow, Sandra; Wagenführ, Katja; Daus, Martin L.; Boerner, Susann; Lemmer, Karin; Thomzig, Achim; Mielke, Martin; Beekes, Michael

Prions are pathogens with an unusually high tolerance to inactivation and constitute a complex challenge to the re-processing of surgical instruments. On the other hand, however, they provide an informative paradigm which ...
2016-09-09Zeitschriftenartikel

Reversible off and on switching of prion infectivity via removing and reinstalling prion sialylation

Katorcha, Elizaveta; Daus, Martin L.; Gonzalez-Montalban, Nuria; Makarava, Natallia; Lasch, Peter; Beekes, Michael; Baskakov, Ilia V.

The innate immune system provides the first line of defense against pathogens. To recognize pathogens, this system detects a number of molecular features that discriminate pathogens from host cells, including terminal ...
2013-03-11Zeitschriftenartikel

Towards further reduction and replacement of animal bioassays in prion research by cell and protein misfolding cyclic amplification assays

Boerner, Susann; Wagenführ, Katja; Daus, Martin L.; Thomzig, Achim; Beekes, Michael

Laboratory animals have long since been used extensively in bioassays for prions in order to quantify, usually in terms of median infective doses [ID50], how infectious these pathogens are in vivo. The identification of ...