2024-06-13Zeitschriftenartikel
Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling
Hobor, Sebastijan; Al Bakir, Maise; Hiley, Crispin T.; Skrzypski, Marcin; Frankell, Alexander M.; Bakker, Bjorn; Watkins, Thomas B. K.; Markovets, Aleksandra; Dry, Jonathan R.; Brown, Andrew P.; van der Aart, Jasper; van den Bos, Hilda; Spierings, Diana; Oukrif, Dahmane; Novelli, Marco; Chakrabarti, Turja; Rabinowitz, Adam H.; Ait Hassou, Laila; Litière, Saskia; Kerr, D. Lucas; Tan, Lisa; Kelly, Gavin; Moore, David A.; Renshaw, Matthew J.; Venkatesan, Subramanian; Hill, William; Huebner, Ariana; Martínez-Ruiz, Carlos; Black, James R. M.; Wu, Wei; Angelova, Mihaela; McGranahan, Nicholas; Downward, Julian; Chmielecki, Juliann; Barrett, Carl; Litchfield, Kevin; Chew, Su Kit; Blakely, Collin M.; de Bruin, Elza C.; Foijer, Floris; Vousden, Karen H.; Bivona, Trever G.; TRACERx consortium; Hynds, Robert; Kanu, Nnennaya; Zaccaria, Simone; Grönroos, Eva; Swanton, Charles
The phenomenon of mixed/heterogenous treatment responses to cancer therapies within an individual patient presents a challenging clinical scenario. Furthermore, the molecular basis of mixed intra-patient tumor responses ...
